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Human immunodeficiency virus (HIV) vaccine candidates were previously constructed as a string of cytotoxic T lymphocyte (CTL) epitopes delivered and expressed using DNA and modified virus Ankara (MVA; an attenuated vaccinia virus) vectors. These vaccines were shown to induce interferon (IFN)-γ-producing and cytolytic CD8 + T cells after a single vaccine administration. In the course of this...
Introduction: Malaria is an increasingly important health problem. The liver stage of infection can be a target for protective cytotoxic T lymphocyte (CTL) responses. Here we evaluate two up-coming recombinant antigen carriers, Ty particles (derived from a yeast retrotransposon protein) and MVA (Modified vaccinia Ankara strain) for their ability to induce T cell responses and protect against a malaria...
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