Search results for: Luigi Serpe

Items from 1 to 14 out of 14 results

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Profiling microcystin contamination in a water reservoir by MALDI-TOF and liquid chromatography coupled to Q/TOF tandem mass spectrometry

Pasquale Ferranti, Serena Fabbrocino, Eugenio Chiaravalle, Milena Bruno, more

Food Research International > 2013 > 54 > 1 > 1321-1330

High resolution mass spectrometry was employed to study a bloom of the Cyanobacterium Planktothrix rubescens in a dam for drinking water on Lake Occhito, near the town of Foggia, in Southern Italy, to characterise the cyanotoxins produced and to evaluate the related health risks for consumers.The cyanotoxin production in various sites of the contaminated dam was studied by MALDI-TOF mass spectrometry...

article

Determination of levamisole in feeds by liquid chromatography coupled to electrospray mass spectrometry on an ion trap

Pasquale Gallo, Serena Fabbrocino, Luigi Serpe

Rapid Communications in Mass Spectrometry > 26 > 7 > 733 - 739

Test methods have to be developed by laboratories for official control to monitor possible misuse of veterinary drugs in animal productions, also through feeding stuff. A novel method for identification and quantification of levamisole in feeds by liquid chromatography coupled to electrospray mass spectrometry in an ion trap (LC/ESI‐MS/MS) is herein described; after a single‐step cleanup by liquid‐liquid...

article

A peptidomic approach for monitoring and characterising peptide cyanotoxins produced in Italian lakes by matrix‐assisted laser desorption/ionisation and quadrupole time‐of‐flight mass spectrometry

Pasquale Ferranti, Antonella Nasi, Milena Bruno, Adriana Basile, more

Rapid Communications in Mass Spectrometry > 25 > 9 > 1173 - 1183

In recent years, the occurrence of cyanobacterial blooms in eutrophic freshwaters has been described all over the world, including most European countries. Blooms of cyanobacteria may produce mixtures of toxic secondary metabolites, called cyanotoxins. Among these, the most studied are microcystins, a group of cyclic heptapeptides, because of their potent hepatotoxicity and activity as tumour promoters...

article

Palytoxin in seafood by liquid chromatography tandem mass spectrometry: investigation of extraction efficiency and matrix effect

Patrizia Ciminiello, Carmela Dell’Aversano, Emma Dello Iacovo, Ernesto Fattorusso, more

Analytical and Bioanalytical Chemistry > 2011 > 401 > 3 > 1043-1050

Blooms of Ostreopsis spp. have been recently reported along the Mediterranean coasts of Spain, France, Italy, and Greece posing serious risks to human health. Occurrence of Ostreopsis spp. may result in palytoxin contamination of seafood and, in order to prevent sanitary risks, the need exists to develop efficient extraction procedures to be coupled to rapid and sensitive monitoring methods of palytoxin-like...

article

New palytoxin-like molecules in Mediterranean Ostreopsis cf. ovata (dinoflagellates) and in Palythoa tuberculosa detected by liquid chromatography-electrospray ionization time-of-flight mass spectrometry

Rachele Rossi, Vincenzo Castellano, Eleonora Scalco, Luigi Serpe, more

Toxicon > 2010 > 56 > 8 > 1381-1387

A rapid, high resolution liquid chromatography coupled with ElectroSpray Ionization Time-Of-Flight Mass Spectrometry (ESI/TOF/MS) method was developed for the determination of the toxin pattern in cultured cells of Ostreopsis cf. ovata from the Mediterranean Sea. The samples were separated on a Phenomenex Luna 3μ HILIC 200A (150 × 2.00 mm) and analyzed by LC/TOF/MS with electrospray ionization (ESI)...

article

Optimisation and validation of an HPLC method for determination of polycyclic aromatic hydrocarbons (PAHs) in mussels

Francesco Paolo Serpe, Mauro Esposito, Pasquale Gallo, Luigi Serpe

Food Chemistry > 2010 > 122 > 3 > 920-925

A method for determination of 11 polycyclic aromatic hydrocarbons (PAHs) in mussels (Mytilus galloprovincialis), using HPLC coupled to a fluorescence detector, has been optimised and validated, according to European Community rules. Sample preparation involves alkaline digestion of mussel tissue, liquid–liquid extraction of organic compounds and solid phase clean-up. Accuracy and precision of the...

article

Confirmatory analysis of non-steroidal anti-inflammatory drugs in bovine milk by high-performance liquid chromatography with fluorescence detection

Pasquale Gallo, Serena Fabbrocino, Geraldine Dowling, Marco Salini, more

Journal of Chromatography A > 2010 > 1217 > 17 > 2832-2839

HPLC with fluorescence detection is considered for confirmatory analysis of group B veterinary drugs by the European Union legislation. A procedure for confirming the presence of anti-inflammatory non-steroidal drug (NSAID) residues in bovine milk by reversed phase high-performance liquid chromatography with fluorescence detection is herein described. The native fluorescence of nine drugs belonging...

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Contamination levels and congener distribution of PCDDs, PCDFs and dioxin-like PCBs in buffalo’s milk from Caserta province (Italy)

Mauro Esposito, Francesco Paolo Serpe, Frank Neugebauer, Stefania Cavallo, more

Chemosphere > 2010 > 79 > 3 > 341-348

An extraordinary plan of official control was carried out in 2008 in Campania (Italy) with the aim to monitor polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (dl-PCBs) levels in buffalo milk and to detect the contaminated farms, most of which are located in Caserta province.For these companies has been ordered seizure and execution of additional...

article

Determination of the banned growth promoter moenomycin A in feed stuffs by liquid chromatography coupled to electrospray ion trap mass spectrometry

Pasquale Gallo, Serena Fabbrocino, Luigi Serpe, Maurizio Fiori, more

Rapid Communications in Mass Spectrometry > 24 > 7 > 1017 - 1024

Flavomycin complex is an antibiotic banned in the European Union as an additive in feed stuffs. As a consequence, the monitoring programmes for official control within the Community require analysis of feeds for possible illegal use of flavomycin. A method for unambiguous identification and quantification of moenomycin A, the main pharmacologically active component of flamomycin complex, in several...

article

Modeling of DR CALUX® bioassay response to screen PCDDs, PCDFs, and dioxin-like PCBs in farm milk from dairy herds

Igor Fochi, Gianfranco Brambilla, Stefania P. De Filippis, Silvia De Luca, more

Regulatory Toxicology and Pharmacology > 2008 > 50 > 3 > 366-375

A recent issue in the EU legislation is the evaluation of the toxicologically-equivalent contribution of dioxin-like polychlorobiphenyls (DL-PCBs) in addition to that coming from polychlorodibenzodioxins (PCDDs) and polychlorodibenzofurans (PCDFs) as contaminants in foods for a total of 29 congeners. This fact is determining the need to revise analytical criteria both for confirmatory and screening...

article

The use of plasmatic acceptors as specific ligands in affinity chromatography cleanup of veterinary drugs from biological matrices

Pasquale Gallo, Antonella Nasi, Floriana Vinci, Maurizio Fiori, more

Analytical and Bioanalytical Chemistry > 2008 > 391 > 4 > 1153-1162

Bovine α₁-acid glycoprotein (bAAG) and bovine serum albumin (BSA) are plasmatic acceptors working as carriers by the specific and reversible binding of several drugs in vivo. We synthesized affinity columns by coupling bAAG and BSA to an activated chromatographic support through their carbohydrate moieties, to preserve protein tertiary structure and, consequently, to improve the biological activity...

article

Purification of clenbuterol-like β2-agonist drugs of new generation from bovine urine and hair by α1-acid glycoprotein affinity chromatography and determination by gas chromatography–mass spectrometry

Pasquale Gallo, Gianfranco Brambilla, Bruno Neri, Maurizio Fiori, more

Analytica Chimica Acta > 2007 > 587 > 1 > 67-74

The control of illegal use of clenbuterol and other β ₂ -agonist drugs as growth promoters in the European Union countries has led to outlaw practices for synthesizing new concept molecules, showing similar biological activity but not detectable by test methods usually employed to perform the official monitoring programmes. The synthesis schemes of some β ₂ -agonist compounds, formally...

article

Residue Study of Ivermectin in Plasma, Milk, and Mozzarella Cheese Following Subcutaneous Administration to Buffalo ( Bubalus bubalis )

Aniello Anastasio, Mauro Esposito, Michele Amorena, Paolo Catellani, more

Journal of Agricultural and Food Chemistry > 2002 > 50 > 18 > 5241 - 5245

article

Determination of nitrofuran residues in avian eggs by liquid chromatography–UV photodiode array detection and confirmation by liquid chromatography–ionspray mass spectrometry

Rosa Draisci, Luigi Giannetti, Luca Lucentini, Luca Palleschi, more

Journal of Chromatography A > 1997 > 777 > 1 > 201-211

A high-performance liquid chromatographic–UV–Vis photodiode-array detection (HPLC–DAD) method for the determination of nitrofuran residues, nitrofurazone, furazolidone and furaltadone, in chicken eggs is described. Confirmation of the identity of nitrofurazone, furazolidone and furaltadone was performed by high-performance liquid chromatography–mass spectrometry (HPLC–MS) using an atmospheric pressure...

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