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Spinocerebellar ataxia 2 (SCA2) is a clinically, pathologically and genetically neurodegenerative disorder. The number of clinical assays in these patients is limited because, among other factors, a lack of biomarkers for the assessment of the main clinical and genetic features of the disease and the evaluation of therapeutic options. The aim of this study was to investigate an extensive array of...
Patients with spinocerebellar ataxia type 2 (SCA2), develop severe pontine nuclei, inferior olives, and Purkinje cell degeneration. This form of autosomal dominant cerebellar ataxia is accompanied by progressive ataxia and dysarthria. Although the motor dysfunction is well characterized in these patients, nothing is known about their motor learning capabilities. Here we tested 43 SCA2 patients and...
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