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Residues 17 and 18 In nef of SIVmac239 were changed from RQ to YE to create a translated sequence of SRP-SGDLYERLLRARGETYGRLLGEVEDGYSOSP from residues 10–43. The YXXL motifs In this context match very well with consensus sequences for SH2 binding domains and are similar to ones present In nef of the acutely lethal pathogen SIVpbj14. The YE variant of SIVmac239, unlike SIVmac239 but like SIVpbj14,...
Few foamy (spuma) retroviruses have been investigated in molecular detail, despite their previous isolation from several mamalian species, including ten neutralization serotypes from various primates. Here, we have studied a new gorilla foamy virus (SFV-Gg) and investigated its functional and phylogenetic relationship to the human (HFV) and other primate foamy viruses, including that recently described...
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