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The present study investigated the role of interferon-inducible pathways in herpes simplex virus type 1-infected mice transduced with an adenoviral vector expressing murine interferon-β (Ad:IFN-β). Wild type mice or RNase L −/− mice deficient in responses to 2′-5′ oligoadenylate synthetase activation, or lacking RNA-dependent protein kinase and transduced with Ad:IFN-β showed enhanced survival...
A study was undertaken to evaluate the efficacy of an adenoviral construct expressing the murine interferon-β (IFN-β) transgene (Ad:IFN-β) against herpes simplex virus type 1 (HSV-1) infection in a primary trigeminal ganglion (TG) cell culture. The transduction efficiency ranged from 0.2 to 11.0% depending on the multiplicity of infection (m.o.i.) of the adenoviral vector (0.5-50.0). Moreover, neurons...
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