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Progesterone (P) is a mineralocorticoid (MC)-antagonist in vitro. During pregnancy, plasma P concentrations exceed aldosterone concentrations at least 50-fold, but plasma aldosterone increases only 4–8-fold in a compensatory manner. Since the in vivo anti-MC activity of P seems to be only moderate, we hypothesized that P is metabolized by enzymes of MC target tissue similar to the way cortisol is...
The 11β-hydroxyl group is essential for glucocorticoid (GC) activity of a steroid. Thus, 11β-hydroxysteroid-dehydrogenases (HSD) are important, because they convert active GCs to their inactive 11-dehydro-products and vice versa. HSD-I is widely distributed and acts mainly as a reductase. In the liver, this isoenzyme activates orally given cortisone (E) or prednisone (Al-dehydro-E) to their 11-hydroxyderivatives...
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