Search results for: Qiang Gu

Items from 1 to 20 out of 191 results

article

Na₂S₂O₃ Catalyzed Three‐Component Synthesis and Anti‐Bacterial Activity of 3‐Methyl‐4‐(hetero)arylmethylene isoxazole‐5(4H)‐ones

Yongchang Bi, Jingjun Wang, Xingyu Bian, Mingyue Chen, more

Chemistry & Biodiversity > 21 > 4 > n/a - n/a

An efficient and green method for synthesizing 3‐methyl‐4‐(hetero) arylmethylene isoxazole‐5(4H)‐ones was developed using a recyclable and environmental–friendly catalyst, Na₂S₂O₃, and 16 target compounds were successfully synthesized under the obtained optimal reaction condition. Using rifampicin as a positive control, the antibacterial activity of all synthesized compounds was tested by micro dilution...

article

Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish

Camila S. Silva, Tetyana Kudlyk, Volodymyr P. Tryndyak, Nathan C. Twaddle, more

Journal of Applied Toxicology > 43 > 12 > 1872 - 1882

Our previous study showed that sodium arsenite (200 mg/L) affected the nervous system and induced motor neuron development via the Sonic hedgehog pathway in zebrafish larvae. To gain more insight into the effects of arsenite on other signaling pathways, including apoptosis, we have performed quantitative polymerase chain reaction array‐based gene expression analyses. The 96‐well array plates contained...

article

Enhanced magnetism in Ru‐doped hybrid improper perovskite Ca₃Mn₂O₇ via experimental and first‐principles study

Kejia Yuan, Hanwen Zhang, Qiang Gu, Tianqi Xiao, more

Journal of the American Ceramic Society > 106 > 4 > 2455 - 2465

The quasi‐2D Ruddlesden–Popper layered perovskites with single‐phase multiferroicity have attracted much attention in recent magnetoelectric memory applications. We have systematically investigated the optical and magnetic properties of Ru‐doped hybrid improper perovskite Ca₃Mn₂O₇ both experimentally and using first‐principles calculations. The Ca₃Ru_xMn₂₋_xO₇ (x = 0, 0.02, 0.06, 0.10) powders were...

article

Shear capacity and lateral stiffness of composite plate shear walls‐concrete encased under cyclic loading

Huafei Wang, Qiang Gu, Yi Qi

The Structural Design of Tall and Special Buildings > 31 > 15 > n/a - n/a

Composite plate shear walls‐concrete encased (C‐PSW/CE), consisting of the steel plates and concrete encasements on one or both sides of the plate, are an excellent lateral force resisting system. This paper theoretically and numerically reveals the shear resisting mechanism of C‐PSW/CE under cyclic loading. The steel web resists the lateral force through in‐plane shear before buckling, and the concrete...

article

Shear force demand for headed stud of composite plate shear walls‐concrete encased under cyclic loading

Huafei Wang, Qiang Gu, Yi Qi

The Structural Design of Tall and Special Buildings > 31 > 6 > n/a - n/a

In composite plate shear walls‐concrete encased (C‐PSW/CE), the headed studs are used to anchor concrete panels on both sides of the infill steel plate and make them resist lateral load together. The finite element models of C‐PSW/CE are developed and validated by testing three C‐PSW/CE specimens under cyclic loading. The responses of the components in C‐PSW/CE under cyclic loading are simulated by...

article

Preparation of an oxyalkylated lignin‐g‐polylactic acid copolymer to improve the compatibility of an organosolv lignin in blended poly(lactic acid) films

Qiang Gu, Thomas L. Eberhardt, Jingjing Shao, Hui Pan

Journal of Applied Polymer Science > 139 > 16 > n/a - n/a

To improve the compatibility of an organosolv lignin (OL) in polylactic acid (PLA) blends, a green approach was pursued whereby the lignin was modified with propylene carbonate (PC) to increase its aliphatic hydroxyl content, and thereby, its reactivity. The oxyalkylated organosolv lignin (OOL, synthesized at 170°C) was analyzed by quantitative ³¹P NMR and showed the number of phenolic hydroxyls decreased...

article

Effect of ketamine on gene expression in zebrafish embryos

Qiang Gu, Jyotshna Kanungo

Journal of Applied Toxicology > 41 > 12 > 2083 - 2089

Ketamine is an N‐methyl‐D‐aspartate (NMDA) receptor antagonist. Used as an anesthetic, potential neurotoxic and cardiotoxic effects of ketamine in animal models have been reported. The underlying mechanisms of ketamine‐induced toxicity are not clear. The zebrafish is an ideal model for toxicity assays because of its predictive capability in chemical testing, which compares well with that of mammalian...

article

Preparation of Zr₃Al₃C₅ ceramic powder by molten salt synthesis

Zihao Chen, Qiang Gu, Weikui Ma, Fan Qian, more

International Journal of Applied Ceramic Technology > 18 > 6 > 1979 - 1987

Methods for synthesising Zr‐based MAX phases powder generally require high temperature and product processing such as milling, which can introduce impurities and high cost. A new method to syntheszse Zr₃Al₃C₅ powder from Zr, Al, and C particles in NaCl‒KCl molten salt was reported. The effects of temperature, Al content, and type of carbon source on the formation of Al–Zr–C compounds were investigated...

article

Effects of acetyl L‐carnitine on zebrafish embryos: Phenotypic and gene expression studies

Qiang Gu, Syed F. Ali, Jyotshna Kanungo

Journal of Applied Toxicology > 41 > 2 > 256 - 264

Acetyl L‐carnitine (ALCAR), a dietary supplement and an antioxidant, plays a vital role in the bioenergetic process that produces ATP. Although there are reports on antioxidant toxicity, there is no information on the potential toxicity of ALCAR. Here, using zebrafish embryos, we explored whether ALCAR modulated ATP synthesis, generation of reactive oxygen species (ROS) and expression of specific...

article

Capacity design for composite partially restrained steel frame‐reinforced concrete infill walls with concealed vertical slits

Guohua Sun, Yuehua Hu, Qiang Gu, Yixin Wang, more

The Structural Design of Tall and Special Buildings > 30 > 1 > n/a - n/a

This paper presents an innovative capacity‐based design procedure that aims to achieve the ideal seismic performance for the composite partially restrained (PR) steel frame‐reinforced concrete (RC) infill wall with concealed vertical slits (PSRCW‐CVS). The proposed method adopts the direct capacity design principles and preselected preferred plastic mechanism such that the RC infill wall undergoes...

article

A rare single nucleotide variant in Pm5e confers powdery mildew resistance in common wheat

Jingzhong Xie, Guanghao Guo, Yong Wang, Tiezhu Hu, more

New Phytologist > 228 > 3 > 1011 - 1026

Powdery mildew poses severe threats to wheat production. The most sustainable way to control this disease is through planting resistant cultivars. We report the map‐based cloning of the powdery mildew resistance allele Pm5e from a Chinese wheat landrace. We applied a two‐step bulked segregant RNA sequencing (BSR‐Seq) approach in developing tightly linked or co‐segregating markers to Pm5e. The...

article

Nifedipine toxicity is exacerbated by acetyl l‐carnitine but alleviated by low‐dose ketamine in zebrafish in vivo

Bonnie L. Robinson, Qiang Gu, Volodymyr Tryndyak, Syed F. Ali, more

Journal of Applied Toxicology > 40 > 2 > 257 - 269

Calcium channel blocker (CCB) poisoning is a common and sometimes life‐threatening emergency. Our previous studies have shown that acetyl l‐carnitine (ALCAR) prevents cardiotoxicity and developmental toxicity induced by verapamil, a CCB used to treat patients with hypertension. Here, we tested whether toxicities of nifedipine, a dihydropyridine CCB used to treat hypertension, can also be mitigated...

article

Protective effect of Shenmai injection on doxorubicin-induced cardiotoxicity via regulation of inflammatory mediators

Sheng Zhang, Zhen-Qiang You, Lin Yang, Li-Li Li, more

BMC Complementary and Alternative Medicine > 2019 > 19 > 1 > 1-10

Background Doxorubicin (DOX) is a chemotherapy drug for malignant tumors. The clinical application of DOX is limited due to its dosage relative cardiotoxicity. Oxidative damage and cardiac inflammation appear to be involved in DOX-related cardiotoxicity. Shenmai injection (SMI), which mainly consists of Panax ginsengC.A.Mey.and Ophiopogon japonicus (Thunb.) Ker Gawl, is widely used for the treatment...

article

High‐performance soluble copolyarylate based on phenolphthalein: synthesis, characterization and properties

Xinghua Guan, Heran Nie, Honghua Wang, Jiyong Zhao, more

Polymer International > 68 > 10 > 1729 - 1738

A series of copolyarylates (PP0–PP100) containing phthalide groups was synthesized via interfacial polymerization from a mixture of phenolphthalein (PP) and bisphenol A with molar equivalent of terephthalyl chloride. Incorporating PP into the polymer chain improved the solubility of the polyarylates in common organic solvents. The glass transition temperature (191–314 °C), residual weight percentage,...

article

RF design and study of a 325 MHz 7 MeV APF IH-DTL for an injector of a proton medical accelerator

Xuan Li, Yue-Hu Pu, Fan Yang, Xiu-Cui Xie, more

Nuclear Science and Techniques > 2019 > 30 > 9 > 1-13

A compact interdigital H-mode drift-tube linac (IH-DTL) with the alternating-phase-focusing (APF) method, working at 325 MHz was designed for an injector of a proton medical accelerator. When fed in with a proper RF (radio frequency) power, the DTL cavity could establish the corresponding electromagnetic field to accelerate the “proton bunches” from an input energy of 3 MeV to an output energy of...

article

Identification in Chinese patients with GLIALCAM mutations of megalencephalic leukoencephalopathy with subcortical cysts and brain pathological study on Glialcam knock-in mouse models

Zhen Shi, Hui-Fang Yan, Bin-Bin Cao, Mang-Mang Guo, more

World Journal of Pediatrics > 2019 > 15 > 5 > 454-464

Background Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare neurological degenerative disorder caused by the mutations of MLC1 or GLIALCAM with autosomal recessive or autosomal dominant inheritance and a different prognosis, characterized by macrocephaly, delayed motor and cognitive development, and bilateral abnormal signals in cerebral white matter (WM) with or without...

article

Power losses caused by longitudinal HOMs in 1.3-GHz cryomodule of SHINE

Jun-Jie Guo, Qiang Gu, Meng Zhang, Zhen Wang, more

Nuclear Science and Techniques > 2019 > 30 > 7 > 1-11

Shanghai high-repetition-rate XFEL and extreme light facility (SHINE), the first hard XFEL based on a superconducting accelerated structure in China, is now under development at the Shanghai Institute of Applied Physics, Chinese Academy of Sciences. In this paper, power losses caused by trapped longitudinal high-order modes (HOM), steady-state loss, and transient loss generated by untrapped HOMs in...

article

Radio-frequency design of a new C-band variable power splitter

Zong-Bin Li, Alexej Grudiev, Wen-Cheng Fang, Qiang Gu, more

Nuclear Science and Techniques > 2019 > 30 > 6 > 1-7

A novel variable C-band radio-frequency (RF) power splitter was designed at Shanghai Institute of Applied Physics, Chinese Academy of Sciences. Using three RF impedance combiners, an H-bend, and an RF polarizer, this new power splitter is much more compact than a traditionally designed splitter, which comprises three 3-dB hybrids. The parameters were optimized to achieve good matching and minimize...

article

Targeted next generation sequencing in 112 Chinese patients with intellectual disability/developmental delay: novel mutations and candidate gene

Huifang Yan, Zhen Shi, Ye Wu, Jiangxi Xiao, more

BMC Medical Genetics > 2019 > 20 > 1 > 1-10

Background Intellectual disability/developmental delay is a complex condition with extraordinary heterogeneity. A large proportion of patients lacks a specific diagnosis. Next generation sequencing, enabling identification of genetic variations in multiple genes, has become an efficient strategy for genetic analysis in intellectual disability/developmental delay. Methods Clinical data of 112 Chinese...

article

A Chinese pedigree with Brown-Vialetto-Van Laere syndrome due to two novel mutations of SLC52A2 gene: clinical course and response to riboflavin

Kaili Shi, Zhen Shi, Huifang Yan, Xiaodong Wang, more

BMC Medical Genetics > 2019 > 20 > 1 > 1-5

Background Brown-Vialetto-Van Laere Syndrome (BVVLS), a rare neurological disorder characterized by motor, sensory, and cranial neuronopathies, is mainly associated with defective riboflavin transporters encoded by SLC52A2 and SLC52A3 genes. Clinical outcomes have been shown to be improved significantly by high-dose riboflavin supplementation. The aim of this study was to identify genetic causes and...

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INFONA - science communication portal

Search results for: Qiang Gu

Na₂S₂O₃ Catalyzed Three‐Component Synthesis and Anti‐Bacterial Activity of 3‐Methyl‐4‐(hetero)arylmethylene isoxazole‐5(4H)‐ones

Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish

Enhanced magnetism in Ru‐doped hybrid improper perovskite Ca₃Mn₂O₇ via experimental and first‐principles study

Shear capacity and lateral stiffness of composite plate shear walls‐concrete encased under cyclic loading

Shear force demand for headed stud of composite plate shear walls‐concrete encased under cyclic loading

Preparation of an oxyalkylated lignin‐g‐polylactic acid copolymer to improve the compatibility of an organosolv lignin in blended poly(lactic acid) films

Effect of ketamine on gene expression in zebrafish embryos

Preparation of Zr₃Al₃C₅ ceramic powder by molten salt synthesis

Effects of acetyl L‐carnitine on zebrafish embryos: Phenotypic and gene expression studies

Capacity design for composite partially restrained steel frame‐reinforced concrete infill walls with concealed vertical slits

A rare single nucleotide variant in Pm5e confers powdery mildew resistance in common wheat

Nifedipine toxicity is exacerbated by acetyl l‐carnitine but alleviated by low‐dose ketamine in zebrafish in vivo

Protective effect of Shenmai injection on doxorubicin-induced cardiotoxicity via regulation of inflammatory mediators

High‐performance soluble copolyarylate based on phenolphthalein: synthesis, characterization and properties

RF design and study of a 325 MHz 7 MeV APF IH-DTL for an injector of a proton medical accelerator

Identification in Chinese patients with GLIALCAM mutations of megalencephalic leukoencephalopathy with subcortical cysts and brain pathological study on Glialcam knock-in mouse models

Power losses caused by longitudinal HOMs in 1.3-GHz cryomodule of SHINE

Radio-frequency design of a new C-band variable power splitter

Targeted next generation sequencing in 112 Chinese patients with intellectual disability/developmental delay: novel mutations and candidate gene

A Chinese pedigree with Brown-Vialetto-Van Laere syndrome due to two novel mutations of SLC52A2 gene: clinical course and response to riboflavin

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