Search results for: Ursula Koppenhoefer

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article

Evidence for a novel function of the CD40 ligand as a signalling molecule in T-lymphocytes

Birgit Brenner, Ursula Koppenhoefer, Heike Grassmé, Jutta Kun, more

FEBS Letters > 1997 > 417 > 3 > 301-306

The interaction of the CD40 receptor with its ligand has been shown to be crucial for the activation of B-lymphocytes. Here, we provide evidence that the pg39 molecule/CD40 ligand (gp39/CD40L) also functions as a stimulatory molecule for T-lymphocytes. Activation of T-lymphocytes via gp39/CD40L induced a strong activation of Jun-N-terminal kinase (JNK) and p38-K. Activation of these kinases correlates...

article

The CD40 Ligand Directly Activates T-Lymphocytes via Tyrosine Phosphorylation Dependent PKC Activation

Birgit Brenner, Ursula Koppenhoefer, Albrecht Lepple-Wienhues, Heike Grassmé, more

Biochemical and Biophysical Research Communications > 1997 > 239 > 1 > 11-17

The activation of B-lymphocytes depends critically on the interaction of the CD40 receptor with its ligand. Here, we provide evidence that the CD40 ligand (CD40L) also functions as a direct stimulatory molecule for T-lymphocytes. Activation of T-lymphocytes via CD40L induces tyrosine phosphorylation of cellular proteins including PLCγ. Tyrosine phosphorylation of PLCγ correlates with an IP3- and Ca...

article

L-Selectin Regulates Actin Polymerisation via Activation of the Small G-Protein Rac2

Birgit Brenner, Erich Gulbins, Gillian L. Busch, Ursula Koppenhoefer, more

Biochemical and Biophysical Research Communications > 1997 > 231 > 3 > 802-807

L-selectin mediated adhesion to endothelial cells is a crucial step in the immune response to pathogens (1, 2) and in lymphocyte homing (3, 4). Selectin molecules mediate leukocyte rolling on endothelial cells, the initial step of adhesion (5, 6). We have previously shown that stimulation of Jurkat T-lymphocytes via L-selectin results in activation of the p21Ras pathway and synthesis of reactive oxygen...

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Keywords

CD40 LIGAND (1)
CD40 LIGAND; GP39; T-LYMPHOCYTES; TYROSINE KINASES; PKC (1)
GP39 (1)
JUN-N-TERMINAL KINASE (1)
T-LYMPHOCYTES (1)
TYROSINE KINASE (1)

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Search results for: Ursula Koppenhoefer

Evidence for a novel function of the CD40 ligand as a signalling molecule in T-lymphocytes

The CD40 Ligand Directly Activates T-Lymphocytes via Tyrosine Phosphorylation Dependent PKC Activation

L-Selectin Regulates Actin Polymerisation via Activation of the Small G-Protein Rac2

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INFONA - science communication portal

Search results for: Ursula Koppenhoefer

Evidence for a novel function of the CD40 ligand as a signalling molecule in T-lymphocytes

The CD40 Ligand Directly Activates T-Lymphocytes via Tyrosine Phosphorylation Dependent PKC Activation

L-Selectin Regulates Actin Polymerisation via Activation of the Small G-Protein Rac2

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