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Purified recombinant listeriolysin O (LLO) was assessed for its ability to induce T cell responses in mice. Intraperitoneal immunisation with LLO, as a fusion with glutathione-S-transferase (GST), induced the production of LLO-specific CD8 + T cells, but not LLO-specific CD4 + T cells. The generation of this response could be blocked by pre-treatment with cholesterol, indicating a...
Clearance of infectious organisms does not always require polarised Th1 or Th2 responses and it may be advantageous for both Th1 and Th2 responses to be elicited for effective protection against an invading pathogen. It was the aim of this study to investigate oxidised mannan as a possible Th1/Th2 adjuvant. Oxidised mannan was conjugated to two candidate antigens and delivered intranasally to mice...
Mannan, oxidatively coupled to recombinant protein antigens, has here been tested as a possible adjuvant for the production of antibody on the mucosa. Given intranasally, but not intraperitoneally, mannan markedly enhanced the production of IgA, IgG1 and IgG2a in the serum, and IgA locally in the lung and at remote mucosal sites, including tears, vaginal and salivary secretions. Oxidative coupling...
Injection of live but not dead bacteria induces a wave of IL-12 and subsequently, IFN-γ production. Surprisingly, in vitro, both live and dead bacteria elicit IL-12 from macrophages. Better understanding of how macrophages distinguish live from dead bacteria would help explain this difference and possibly bypass the need for live vaccines against intracellular bacteria.
Following intranasal infection of mice withMycobacterium aviumcomplex (MAC) organisms, bacterial growth plateaued at the fourth week postinfection and then remained relatively constant thereafter. Inflammatory cell numbers in the lungs increased 10-fold by 4 weeks postinfection, and lung cell cytotoxicity and the production of NO, H 2 O 2 , and O −2 by lung cell cultures...
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