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A neuropathological hallmark of Alzheimer's disease is the presence of amyloid plaques. The major constituent of these plaques, occurring largely in brain areas important for memory and cognition, is the 40-42 amyloid residues (Aβ). Aβ is derived from the amyloid protein precursor after cleavage by the recently identified β-secretase (BACE1) and the putative γ-secretase complex containing presenilin...
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