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We investigated the transfer of three antioxidants - melatonin, S-adenosyl methionine (SAM) and various forms of vitamin E - across the term, normal human placenta. The transport technique involved the single, isolated placental cotyledon system in vitro. Melatonin crossed the placenta rapidly, equally to the freely diffusible marker, antipyrine. There was no biotransformation of the agent. SAM was...
LEARNING OUTCOME: To examine vitamin E transport across the placenta using perfused, human placentas.Vitamin E sufficiency has been an on-going concern in premature and term infants. Transfer of vitamin E across the human placenta has only been examined in evaluating cord blood following parturition and in animal models using a single cotyledon. With the modification of an animal organ perfusion chamber,...
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