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A hypercholesterolemic diet has been associated with the hepatic abnormalities and the pathological processes of systemic lupus erythematosus (SLE). To investigate the effects of taurine on the hepatic abnormality in SLE, NZB/W F1 mice were used as an animal model by receiving control, cholesterol, or cholesterol+taurine diets, respectively. Reductions (P<0.05) of liver-to-body weight ratio, lipid...
Increased population with hepatic diseases and apoptosis were found in patients with SLE and implicated in the pathogenesis of SLE. Since cystamine has been demonstrated to be beneficial to NZB/W F1 mice in our previous report, this study intends to investigate the effects of cystamine in liver from NZB/W F1 mice. Decreased apoptosis was detected in liver from NZB/W F1 mice given cystamine as compared...
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