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The nocturnal decline of blood pressure (BP) is almost coincident with the elevation of melatonin, which may exert vasodilatating and hypotensive effects. In this study we investigated whether prolonged nocturnal administration of melatonin could influence the daily rhythm of BP in women. In a randomized double-blind study, 18 women, 47 to 63 years of age and with normal BP (N = 9) or treated essential...
Objective: To evaluate the central effect exerted by different progestins used for hormone replacement therapy. Methods: Randomised, placebo-controlled study. One hundred-twenty postmenopausal women on continuous hormonal replacement therapy with transdermal estradiol (50μg per day) associated, for 10 days every 28 days, with four different progestins: dydrogesterone (DYD; 10mg per day; n=20), medroxyprogesterone...
Objective: Elevation of blood pressure and heart rate increase the risk of cardiovascular disease. Administration of estrogens does not affect heart rate but may decrease 24h blood pressure. In this study, we tested the effect of the estro-progestogenic compound tibolone. Methods: Thirty healthy, post-menopausal women were randomized to receive placebo (n=15) or tibolone, at the commonly prescribed...
Genetic hyperhomocysteinemia is associated with skeletal abnormalities and osteoporosis. We tested whether levels of homocysteine and critical co-enzymes of homocysteine metabolism, such as vitamin B 12 and folate, are related to lumbar spine bone mineral density (BMD) measured by DEXA in 161 postmenopausal women. Folate but not homocysteine or vitamin B 12 , was lower in...
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