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Injection of manganese into the eye will enhance the contrast of visual system neuronal pathways imaged by MRI (MEMRI). The present study was undertaken to determine the effect of a range of MnCl 2 doses upon the integrity of various ocular structures. Anesthetized mice received ocular anterior chamber injections of 50–500 nmol of MnCl 2 . One week later, the eyes were fixed, embedded...