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Neurogenic differentiation factor 2 (NeuroD2) is a highly expressed transcription factor in the developing central nervous system. In newborn neurons, NeuroD2‐mediated gene expression promotes differentiation, maturation, and survival. In addition to these early, cell‐intrinsic developmental processes, NeuroD2 in postmitotic neurons also regulates synapse growth and ion channel expression to control...
Cover illustration: The cover image, by Fading Chen and Benjamin J. Hall, is based on the Research Article Synaptic activity suppresses expression of neurogenic differentiation factor 2 in an NMDA receptor‐dependent manner, DOI: 10.1002/syn.21986.
Key pointsSynaptic excitation and inhibition must be properly balanced in individual neurons and neuronal networks to allow proper brain function.Disrupting this balance may lead to autism spectral disorders and epilepsy.We show the basic helix–loop–helix transcription factor NeuroD2 promotes inhibitory synaptic drive but also decreases cell‐intrinsic neuronal excitability of cortical pyramidal neurons...
Neurexins are highly polymorphic cell-surface adhesive molecules in neurons. In cultured mammalian cell system, they were found to be involved in synaptogenesis. Here, we report for the first time that Drosophila neurexin is required for synapse formation and associative learning in larvae. Drosophila genome encodes a single functional neurexin (CG7050; Neurexin-1 or Nrx-1), which is a homolog of...
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