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Multicomponent lipid bilayer membranes display rich phase transition and associated compositional lipid domain formation behavior. When both leaflets of the bilayer contain domains, they are often found co-localized across the leaflets, implying the presence of a thermodynamic interleaflet coupling. In this work, it is demonstrated that fluctuation-induced interactions between domains embedded within...
Phase transitions driven by intrinsically disordered protein regions (IDRs) have emerged as a ubiquitous mechanism for assembling liquid-like RNA/protein (RNP) bodies and other membrane-less organelles. However, a lack of tools to control intracellular phase transitions limits our ability to understand their role in cell physiology and disease. Here, we introduce an optogenetic platform that uses...
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