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The right hindlimbs of 24-month-old female Wistar rats were immobilised for 4weeks using external fixation of the knee joint. In a further group, after the external fixation was removed, the rats were allowed to remobilise for an additional 4weeks. Hindlimb immobilisation for 4weeks caused a 32-42% reduction in wet weights of the hindlimb muscles of the rats as compared to those of the contralateral...
Head-and-neck irradiation in rats often results in reduction of water and food intake, weight loss, hyposalivation, and suppression of the white blood cell (WBC) count. Oxygen free radicals are believed to be involved in this deleterious process. Superoxide dismutase (SOD) is known to act as a first line of antioxidant defence against oxygen free radicals. Here, the protective effect of manganese...
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