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Using diffuse optical tomography we have imaged early vascular responses to anti-angiogenic treatments in a small animal tumor model. Images acquired from 1 to 7 days after drug administration show measurable changes in hemoglobin concentration. There are observable differences between mice treated with anti-angiogenic drugs and mice that receive a placebo treatment.
Micrometer-sized microcapsules collapse upon exposure to ultrasound. Use of this phenomenon for a drug delivery system (DDS), not only for local delivery of medication but also for gene therapy, should be possible. However, enhancing the efficiency of medication is limited because capsules in suspension diffuse in the human body after injection, since the motion of capsules in blood flow cannot be...
Oscillometric method is the method for the blood pressure measurement using mean arterial pressure (MAP). In the conventional method, the cuff pressure at the largest pulse is determined as MAP. However, it is difficult to find the largest oscillometric pulse from patients who have the cardiovascular disease or the elder subjects. Therefore, we studied a new method to determine the MAP by analyzing...
We describe the first mapping of biological current in a live heart using ultrasound current source density imaging (UCSDI). Ablation procedures that treat severe heart arrhythmias require detailed maps of the cardiac activation wave. UCSDI can potentially improve on existing mapping procedures which are time-consuming and limited by its poor spatial resolution (5-10 mm). UCSDI is based on a pressure-induced...
Ultrasound strain imaging has been proposed to quantitatively assess myocardial contractility. Cross-correlation based 2D speckle tracking (ST) and auto-correlation based Doppler tissue imaging (DTI) are competitive ultrasound techniques for this application. Unlike ST, DTI is limited by angle dependency and suffers from low signal-to-noise ratio because a high pulse repetition frequency (PRF) is...
Cardiac motion related artifact in ultrasound induced thermal strain imaging (TSI) was reduced in-vitro and in-vivo using ECG gating. Tissue motion due to the heart beat is a major challenge for in-vivo TSI application, especially for cardiovascular systems. Temporal variation of the relative position between the transducer and the artery will induce decorrelation in speckle tracking. Tissue deformation...
An optimized elastic modulus reconstruction procedure from ultrasound strain and pulse wave velocity (PWV) measurements was validated using a commercial ultrasound scanner. Longitudinal and transverse scans were performed on a vessel phantom connected to a pulsatile pump. Time delay between the ultrasound beams at each side of the transducer determines PWV and transverse elasticity imaging estimates...
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