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We investigated the action of the quaternary ammonium salt (QAS) called IM (N-(dodecyloxycarboxymethyl)-N,N,N-trimethyl ammonium chloride) on Saccharomyces cerevisiae yeast cells. Changes in the yeast cell ultrastructure were confirmed by electron microscopy. We treated resistant mutant cells with QAS, and confirmed destruction of the mutant cytoplasm, an increase in the thickness of the cell wall,...
The yeast ACR1 gene encodes a putative transcriptional regulatory bZIP protein involved in the arsenical resistance. We demonstrate that the ACR2 and ACR3 genes are positively regulated by Acr1p. Changes in the ACR1 gene dosage influence the ACR2-lacZ and ACR3-lacZ fusion genes response to the arsenite induction. Arsenic and antimony compounds, but not bismuth and cadmium salts, strongly induced the...
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