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WWOX is a tumour suppressor gene affected in multiple cancers, especially in breast, prostate and ovary. This gene is located at the chromosomal area 16q23.3-24.1, which was identified as a common chromosomal fragile site FRA16D. WWOX turned out to possess tumour suppressor features despite the fact that the most basic (classical) way of tumour suppressor gene inactivation involves both alleles (e...
The molecular determination of viral load in the serum represents the most valuable prognostic marker of HBV infection. In this paper, a new molecular assay for the quantitative measurement of HBV presence is described. It is based on PCR performing with a HBV-specific competitor DNA template. For the construction of the DNA template, a HBV DNA-originated 436 bp DNA fragment was modified by introducing...
Effects of thiram on the process of disturbances of development in consequence of transplacentar exposure were studied in rats. Analysis was performed in descendants born by females exposed to thiram (orally by gavage) for the first time pregnancy and born by females from third generation exposed to the fungicide (multigeneration exposure by food with thiram). In the conditions of two experiments...
Embrotoxic and teratogenic effects of carbendazim were examined in Wistar rats for the product containing 98% a.i. of carbendazim and diaminophenazine contamination level of 1,1 ppm. The compound was administered by the oral route to pregnant rats during the organogenetic phase of gestation at doses: 0; 15, 30, 45 mg/kg b.w. and in the other group in diets at the concentration 2000 ppm. We found that...
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