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Gliptins are anti‐type 2 diabetes (T2D) drugs that regulate glycaemia by preventing endogenous glucagon‐like peptide‐1 (GLP‐1) degradation. Chronically administered gliptins before experimental stroke can also induce neuroprotection, and this effect is potentially relevant for reducing brain damage in patients with T2D and high risk of stroke. It is not known, however, whether acute gliptin treatment...
BACKGROUND AND AIM: Transient focal cerebral ischemia is stimulus triggering reactive astroglial response characterized as the cellular proliferation and restoring of differentiation abilities necessary for reduction of the consequences of primary brain lesion and separation of ischemia. Growing evidence of data point to specific, context-dependent character of this response dependent from the pathological...
It is postulated that stress differentially affects interleukin-ip (IL-ip) during ontogenetic life. This study examined the influence of chronic exposure to forced swim (FS) stress or high-light open-field (HL-OF) stress on interleukin-ip (IL-ip). The total level of IL-ip protein was assessed by Western blot analysis of hippocampal extracts. Double immunofluorescence staining was used to reveal the...
The aim of this study was to investigate the influence of two periods of life, namely P28 and P360, on the changes in interleukin-1beta (IL-1β) immunoreactivity (-ir) in the hippocampus (CA1, CA3, DG) and amygdala (central-CeA, medial-MeA) caused by acute and repeated open field (OF), or by forced swim (FS) exposition. Rats were divided into groups: non-stressed, exposed to acute (one-time for 15...
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