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Macrophages (Mf) play an important role in induction and regulation of the immune response. It was shown previously that subcutaneous injection of hapten conjugated macrophages (TNP-Mf) induces the contact hypersensitivity (CHS) response, whereas intravenous (i.v.) or intraperitioneal administration of TNP-Mf results in unresponsiveness as a result of induced T suppressor (Ts) cells. The aim of this...
Delayed-type hypersensitivity (DTH) is a T cell-mediated immune reaction that plays a major role in the pathogenesis of various infl ammatory disorders. One of the most characteristic DTH phenomena is contact hypersensitivity (CS) used to assess cellmediated immunity against tumor cells and microbes that survive within macrophages. Recently it was suggested that activation of immune system plays a...
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