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INTRODUCTION: The brain has developed several endogenous mechanisms to protect itself from the harm ful consequences of ischemia/reperfusion (I/R) injury. Understanding of such mechanisms may be important for the development of new neuroprotective therapies. In a gerbil model of cerebral ischemia, 5 min-ischemia results in selective, delayed neuronal death in the hippocampal CA1 region, while CA2‑4...
Mitochondrial homeostasis, resulting from fusion and fission processes together with mitophagy and mitogenesis, are widely studied nowadays. This is probably because we know more and more about the role of mitochondria in metabolic diseases (diabetes, hypertension), neurodegeneration (Parkinson’s Disease, Alzheimer’s Disease), but also in broad spectrum of inherited neurological syndromes (CharcotMarie-Tooth)...
Transient cerebral ischemia is known to induce endogenous adaptive mechanisms such as the activation of mitochondrial ATP regulated or Ca2+ regulated large conductance potassium channels that can prevent or delay neuronal injury. However, molecular mechanism of this effect remains unclear. In this study, a single channel activity was measured with patch-clamp of the mitoplasts isolated from gerbil...
Transient cerebral ischemia is known to induce endogenous adaptive mechanisms such as the activation of mitochondrial ATP-sensitive potassium channels or calcium-sensitive largeconductance potassium channels that can prevent or delay neuronal injury. In this study a single channel activity was measured after patch-clamp of the mitoplasts isolated from control gerbil hippocampus. In 70% of the all...
PKC is implicated in the regulation of mitochondrial membranes integrity, however its precise function is not fully understood. We have examined association of PKCβ with mitochondria isolated from ischemia-vulnerable (CA1) and ischemia-resistant (CA2-3, DG) hippocampal regions in gerbil model of transient brain ischemia. We show that ischemia-induced translocation of PKCβ to mitochondria in (CA2-3,DG)...
Biphalin is a dimeric opioid peptide, that exhibits a high affi nity for all three opioid receptors types (miu, delta and kappa). When administered intracerebroventricularly it has been shown to be more potent than morphine and ethorphine at eliciting antinociception. Biphalin is currently undergoing intensive preclinical study. It is recognized in recent years that activation of delta-opioid receptor...
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