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Ciprofloxacin is widely used in antimicrobial therapy. However it also inhibits mitochondrial topoisomerase II and therefore affects cellular energy metabolism. At a concentration exceeding 80 µg/ml ciprofloxacin induces apoptosis, while at 25 µg/ml it inhibits proliferation of Jurkat cells without any symptoms of cell death. The aim of this study was to explain the mechanisms of ciprofloxacin-evoked...
We compared the in vitro propensity of human IL-2-dependent lymphocytes (young proliferating and senescent non-proliferating), and resting peripheral blood lymphocytes (PBLs) to undergo UVC-induced apoptosis. The activities of AP-1 (activator protein-1), CRE (cAMP response element) and OCT-1 (octamer-1) transcription factors in all lymphocytes were also assessed. At 24h after UVC treatment, half of...
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