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This chapter discusses numerous aspects of multiscale molecular modeling for drug delivery, including multiscale computational methods, micellar self assembly and stability, the interaction of drugs with polymers and membranes, as well as the kinetics of drug binding. Micellar self‐assembly and stability, the interaction of drugs with polymers and membranes, as well as the kinetics of drug binding...
Cellular organization within a multicellular organism requires that a cell assess its relative location, taking in multiple cues from its microenvironment. Given that the extracellular matrix (ECM) consists of the most abundant proteins in animals and contributes both structure and elasticity to tissues, ECM probably provides key physical cues to cells. In vivo, in the vicinity of many tissue cell...
Cell migration through solid tissue often involves large contortions of the nucleus, but biological significance is largely unclear. The nucleoskeletal protein lamin-A varies both within and between cell types and was shown here to contribute to cell sorting and survival in migration through constraining micropores. Lamin-A proved rate-limiting in 3D-migration of diverse human cells that ranged from...
Delivery of antisense oligonucleotides, AON, presents many of the same challenges as delivery of any nucleic acid: charge, stability, cell uptake, endolysosomal escape, and entry into the nucleus. Here we demonstrate efficient delivery of AON after loading into biodegradable polymer vesicles or `polymersomes'. We focus on AON delivery to muscle cells in vitro and in vivo because of the emergence of...
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