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We characterize Rv0474, a putative transcriptional regulatory protein of Mycobacterium tuberculosis, which is found to function as a copper‐responsive transcriptional regulator at toxic levels of copper. It is an autorepressor, but at elevated levels (10–250 μm) of copper ions the repression is relieved resulting in an increase in Rv0474 expression. Copper‐bound Rv0474 is recruited to the rpoB promoter...
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