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Screening for new anticancer agents has traditionally been done with in vitro cell culture methods. Even in the genomic era of target-driven drug design, screening for cytotoxic activity is still a standard tool in the search for new anticancer agents, especially if the mode of action of a substance is not yet known. A wide variety of cell culture methods with unique end-points are available for testing...
A series of Cu(II), Co(II), Pt(II) and Zn(II) coordination compounds has been prepared by the reaction of the metal chlorides with pyrazine‐2‐carboxylic acid, pyridine‐2‐carboxylic acid, imidazole‐4‐carboxylic acid, benzimidazole‐2‐carboxylic acid and 1‐methylimidazole‐2‐carboxylic acid. The complexes were characterized by IR, UV‐VIS, elemental analysis, and some by 1H‐NMR, X‐ray crystallography,...
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