Search results for: Atsushi Yoshizawa

Items from 1 to 20 out of 55 results

article

Increased Expressions of Programmed Death Ligand 1 and Galectin 9 in Transplant Recipients Who Achieved Tolerance After Immunosuppression Withdrawal

Nguyen Hai Nam, Kojiro Taura, Yukinori Koyama, Takahiro Nishio, more

Liver Transplantation > 28 > 4 > 647 - 658

Programmed death 1 (PD1)/its ligand PD‐L1 concomitant with T cell immunoglobulin and mucin domain‐containing protein 3 (TIM‐3)/its ligand galectin 9 (Gal‐9) and the forkhead box P3 (FOXP3) might be involved in tolerance after liver transplantation (LT). Liver biopsies from 38 tolerant, 19 nontolerant (including 16 samples that triggered reintroduction of immunosuppression [IS] and 19 samples after...

article

Long‐term Outcomes of Stent Placement Inside the Bile Duct for Biliary Strictures After Living Donor Liver Transplantation

Yoshihiro Nishikawa, Norimitsu Uza, Koichiro Hata, Saiko Marui, more

Liver Transplantation > 28 > 1 > 88 - 97

In living donor liver transplantation (LDLT), anastomotic biliary stricture is a serious and refractory complication. In this study, we reviewed the transition of post‐LDLT anastomotic biliary strictures and evaluated long‐term outcomes of stent placement inside the bile duct, which is referred to as an “inside‐stent.” Of 805 consecutive adult LDLT recipients in our institution (2000‐2018), we reviewed...

article

The impact of chronic Epstein–Barr virus infection on the liver graft of pediatric liver transplant recipients: A retrospective observational study

Masato Shizuku, Hideya Kamei, Atsushi Yoshizawa, Yoshinori Ito, more

Transplant Infectious Disease > 23 > 5 > n/a - n/a

Background Chronic high Epstein–Barr virus loads (CHEBV) are commonly observed in pediatric liver transplant patients. However, it is unclear how CHEBV impacts the liver graft. The aim of this study was to clarify the clinical and pathological impacts of CHEBV on the liver graft. Methods From 2012 to 2020, we retrospectively investigated 46 pediatric liver transplant patients (under 16 years) who...

article

Donor age (≥45 years) and reduced immunosuppression are associated with the recurrent primary sclerosing cholangitis after liver transplantation – a multicenter retrospective study

Nobuhisa Akamatsu, Kiyoshi Hasegawa, Hiroto Egawa, Hideki Ohdan, more

Transplant International > 34 > 5 > 916 - 929

The present study investigated the possible risk factors, including relationship/HLA matching between donor and recipient, and immunosuppressive therapies on the recurrence of primary sclerosing cholangitis (PSC) after liver transplantation (LT). Subjects were 197 recipients of LT for PSC, among whom 180 surviving more than 1 year after LT were further analyzed for risk factors of recurrence. The...

article

Donor‐dominant one‐way matching of human leukocyte antigen‐A/B/DR alleles predicts graft‐versus‐host disease following living donor liver transplantation

Masaaki Hirata, Shintaro Yagi, Takero Shindo, Atsushi Yoshizawa, more

Hepatology Research > 51 > 1 > 135 - 148

Aim Graft‐versus‐host disease (GVHD) following liver transplantation is rare but fatal. Therefore, it is important to identify possible risk factors before transplantation. Although it has been suggested that donor‐dominant one‐way human leukocyte antigen (HLA) matching of three loci (HLA‐A/B/DR) is associated with the occurrence of GVHD, the precise significance of HLA matching including HLA‐C/DQ/DP...

article

Pediatric liver transplantation for neonatal‐onset Niemann‐Pick disease type C: Japanese multicenter experience

Naoya Yamada, Ayano Inui, Yukihiro Sanada, Yoshiyuki Ihara, more

Pediatric Transplantation > 23 > 5 > n/a - n/a

Niemann‐Pick disease type C (NPC) is a rare autosomal recessive inherited disease characterized by lysosomal accumulation of free cholesterol in macrophages within multiple organs. Infantile‐onset NPC often presents with jaundice and hepatosplenomegaly from birth, but these symptoms usually improve during early childhood, and it rarely progresses to liver failure. We report three cases from different...

article

Early post‐operative intravenous tacrolimus in pediatric liver transplant recipients is not superior to oral tacrolimus

Tarek Abdelazeem Sabra, Hideaki Okajima, Atsushi Yoshizawa, Eri Ogawa, more

Pediatric Transplantation > 23 > 3 > n/a - n/a

We aimed to compare the early results of i.v. with p.o. TAC as a primary immunosuppressant in pediatric patients undergoing LT. This retrospective study enrolled 75 children who underwent LT and received TAC‐steroid regimens as a primary immunosuppressant between September 2011 and October 2015 at our institution. Thirty‐five recipients received TAC i.v. and 40 received TAC p.o. Early results were...

article

Impact of pretreatments on outcomes after living donor liver transplantation for hepatocellular carcinoma

Kohei Ogawa, Toshimi Kaido, Hideaki Okajima, Yasuhiro Fujimoto, more

Journal of Hepato‐Biliary‐Pancreatic Sciences > 26 > 2 > 73 - 81

Background The purpose of this study was to examine the impact of pretreatments on outcomes after living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC). Methods From February 1999 to March 2015, 223 patients underwent LDLT for HCC. Until December 2006, there was no restriction in patient selection criteria regarding the number and size of tumors, following which we implemented...

article

Cytomegalovirus infection in pediatric patients with hepatoblastoma after liver transplantation

Seishiro Nodomi, Katsutsugu Umeda, Itaru Kato, Satoshi Saida, more

Pediatric Transplantation > 22 > 7 > n/a - n/a

No studies have examined CMV infection in pediatric patients with HB receiving LT. Here, we retrospectively analyzed the incidence of and risk factors for CMV infection in 24 pediatric patients with HB who underwent LT between 1997 and 2015. CMV infection was monitored by measuring expression of pp65 CMV antigen for up to 4 months post‐LT. CMV infection, defined as detection of at least one pp65‐positive...

article

The use of hepatitis B immunoglobulin with or without hepatitis B vaccine to prevent de novo hepatitis B in pediatric recipients of anti‐HBc–positive livers

Noriyo Yamashiki, Atsushi Yoshizawa, Yoshihide Ueda, Toshimi Kaido, more

Pediatric Transplantation > 22 > 5 > n/a - n/a

Prophylactic measures are used to reduce DNHB after HBsAg‐negative patients receive anti‐HBc–positive liver grafts. This study investigated the incidence of DNHB and clinical outcomes in pediatric LT recipients under HBIG prophylaxis, with or without hepatitis B vaccination. Between 1995 and 2013, 51 HBsAg‐negative pediatric recipients underwent living‐donor LT from anti‐HBc–positive donors. The median...

article

The Impact of Preoperative Hemoglobin Level on the Short-Term Outcomes After Living Donor Liver Transplantation

Amr Badawy, Toshimi Kaido, Ahmed Hammad, Shintaro Yagi, more

World Journal of Surgery > 2018 > 42 > 12 > 4081-4089

Background Preoperative anemia was reportedly associated with increased morbidity and mortality after various types of surgeries. However, its impact on the outcomes after liver transplantation has not been thoroughly investigated. Methods We retrospectively investigated the clinical outcome of 216 consecutive adult patients who underwent living donor liver transplantation at our institute between...

article

Human leukocyte antigen compatibility and lymphocyte cross‐matching play no significant role in the current adult‐to‐adult living donor liver transplantation

Amr Badawy, Toshimi Kaido, Atsushi Yoshizawa, Shintaro Yagi, more

Clinical Transplantation > 32 > 4 > n/a - n/a

Background The impact of human leukocyte antigen (HLA) compatibility and positive lymphocyte cross‐match (LCM) on organ transplantation is well‐recognized particularly in kidney and heart transplantation; however, it is still debatable in liver transplantation (LT). So, the aim of this study was to evaluate the impact of HLA mismatch and positive LCM on the outcome of LT. Methods We retrospectively...

article

Prognostic and therapeutic factors influencing the clinical outcome of hepatoblastoma after liver transplantation: A single‐institute experience

Katsutsugu Umeda, Hideaki Okajima, Koji Kawaguchi, Seishiro Nodomi, more

Pediatric Transplantation > 22 > 2 > n/a - n/a

LT has contributed to an elevation in cure rates for patients with unresectable HB; however, patients with recurrent HB after LT have poor prognosis. To analyze the prognostic and therapeutic factors that influence the clinical outcome of patients with HB receiving LT, we retrospectively analyzed 24 patients with HB who underwent LT between 1997 and 2015. The 5‐year OS rate of all patients was 69...

article

Portal vein reconstruction using vein grafts in pediatric living donor liver transplantation: Current status

Tarek Abdelazeem Sabra, Hideaki Okajima, Atsushi Yoshizawa, Tatsuya Okamoto, more

Pediatric Transplantation > 21 > 3 > n/a - n/a

PV reconstruction is an important aspect of LDLT, with post‐transplant outcomes depending on PV reconstruction methods. However, it is unclear whether the preferential selection of these techniques is dependent on preoperative recipient characteristics. This retrospective study assessed whether preoperative recipient factors differed in pediatric patients who did and did not receive VGs for PV reconstruction...

article

New-onset diabetes mellitus after living-donor liver transplantation: association with graft synthetic function

Shintaro Yagi, Toshimi Kaido, Taku Iida, Atsushi Yoshizawa, more

Surgery Today > 2017 > 47 > 6 > 733-742

Background and purpose It is now known that post-transplant graft function after deceased-donor liver transplantation and living-donor liver transplantation (LDLT) differ; however, there is no report assessing the relationship between graft function and the development of new-onset diabetes mellitus after transplantation (NODAT). We conducted this study to identify the predictive risk factors for...

chapter

A Singularity-Free GFDM Modulation Scheme with Parametric Shaping Filter Sampling

Atsushi Yoshizawa, Ryota Kimura, Ryo Sawai

2016 IEEE 84th Vehicular Technology Conference (VTC-Fall) > 1 - 5

2016 IEEE 84th Vehicular Technology Conference (VTC-Fall)

A GFDM modulation scheme that circumvents the singularity issue of the GFDM transformation matrix is presented. The coefficients used for the pulse shaping filter are derived from the prototype filter depending on the parity of the subsymbols. The proposed pulse shaping filter design makes it possible to have a non-singular transformation matrix for the arbitrary number of subsymbols and/or subcarriers...

article

How far can we lower graft-to-recipient weight ratio for living donor liver transplantation under modulation of portal venous pressure?

Tadahiro Uemura, Seidai Wada, Toshimi Kaido, Akira Mori, more

Surgery > 2016 > 159 > 6 > 1623-1630

Smaller size grafts for living donor liver transplantation (LDLT) can enhance donor safety and expand donor availability. We previously reported that modulation of portal venous pressure (PVP) was key for successful LDLT with small grafts, and that it actively lowered graft-to-recipient weight ratio (GRWR) for adult-to-adult LDLT. This retrospective study investigated the outcome of LDLT using small...

article

Long‐term efficacy of hepatitis B vaccination as post‐transplant prophylaxis in hepatitis B surface antigen (HBsAg) positive recipients and HBsAg negative recipients of anti‐hepatitis B core positive grafts

Atsushi Yoshizawa, Noriyo Yamashiki, Yoshihide Ueda, Toshimi Kaido, more

Hepatology Research > 46 > 6 > 541 - 551

AimHepatitis B virus (HBV) reactivation after liver transplantation in HBV patients, or in HBV negative recipients of anti‐hepatitis B core (HBc) positive grafts, has been prevented by prophylactic use of hepatitis B immunoglobulin (HBIG) and/or nucleoside/nucleotide analogs (NA). Vaccination against HBV is an alternative that may provide a chance to discontinue prophylaxis by producing anti‐hepatitis...

article

p53-independent structure-activity relationships of 3-ring mesogenic compounds’ activity as cytotoxic effects against human non-small cell lung cancer lines

Saori Fukushi, Hironori Yoshino, Atsushi Yoshizawa, Ikuo Kashiwakura

BMC Cancer > 2016 > 16 > 1 > 1-14

Background We recently demonstrated the cytotoxicity of liquid crystal precursors (hereafter referred to as “mesogenic compounds”) in the human non-small cell lung cancer (NSCLC) cell line A549 which carry wild-type p53. p53 mutations are observed in 50 % of NSCLC and contribute to their resistance to chemotherapy. To develop more effective and cancer-specific agents, in this study, we investigated...

article

Anti-inundation Measures for Underground Stations of Tokyo Metro

Yoji Aoki, Atsushi Yoshizawa, Tomoya Taminato

Procedia Engineering > 2016 > 165 > C > 2-10

Tokyo Metro Co., Ltd. (hereinafter, Tokyo Metro) comprises nine lines operating over 195.1km and 179 stations, and is used by 7.07 million passengers per day. Tokyo Metro operates on the belief that security equals safety plus service. In regard to safety, special effort is devoted toward countermeasures for natural disasters. In light of recent extreme weather events, countermeasures for heavy rains...

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Search results for: Atsushi Yoshizawa

Increased Expressions of Programmed Death Ligand 1 and Galectin 9 in Transplant Recipients Who Achieved Tolerance After Immunosuppression Withdrawal

Long‐term Outcomes of Stent Placement Inside the Bile Duct for Biliary Strictures After Living Donor Liver Transplantation

The impact of chronic Epstein–Barr virus infection on the liver graft of pediatric liver transplant recipients: A retrospective observational study

Donor age (≥45 years) and reduced immunosuppression are associated with the recurrent primary sclerosing cholangitis after liver transplantation – a multicenter retrospective study

Donor‐dominant one‐way matching of human leukocyte antigen‐A/B/DR alleles predicts graft‐versus‐host disease following living donor liver transplantation

Pediatric liver transplantation for neonatal‐onset Niemann‐Pick disease type C: Japanese multicenter experience

Early post‐operative intravenous tacrolimus in pediatric liver transplant recipients is not superior to oral tacrolimus

Impact of pretreatments on outcomes after living donor liver transplantation for hepatocellular carcinoma

Cytomegalovirus infection in pediatric patients with hepatoblastoma after liver transplantation

The use of hepatitis B immunoglobulin with or without hepatitis B vaccine to prevent de novo hepatitis B in pediatric recipients of anti‐HBc–positive livers

The Impact of Preoperative Hemoglobin Level on the Short-Term Outcomes After Living Donor Liver Transplantation

Human leukocyte antigen compatibility and lymphocyte cross‐matching play no significant role in the current adult‐to‐adult living donor liver transplantation

Prognostic and therapeutic factors influencing the clinical outcome of hepatoblastoma after liver transplantation: A single‐institute experience

Portal vein reconstruction using vein grafts in pediatric living donor liver transplantation: Current status

New-onset diabetes mellitus after living-donor liver transplantation: association with graft synthetic function

A Singularity-Free GFDM Modulation Scheme with Parametric Shaping Filter Sampling

How far can we lower graft-to-recipient weight ratio for living donor liver transplantation under modulation of portal venous pressure?

Long‐term efficacy of hepatitis B vaccination as post‐transplant prophylaxis in hepatitis B surface antigen (HBsAg) positive recipients and HBsAg negative recipients of anti‐hepatitis B core positive grafts

p53-independent structure-activity relationships of 3-ring mesogenic compounds’ activity as cytotoxic effects against human non-small cell lung cancer lines

Anti-inundation Measures for Underground Stations of Tokyo Metro

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