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Nuclear factor–κB (NF–κB) is an important nuclear transcription factor which regulates pro‐inflammatory cytokines such as TNF‐α, IL‐6. Its role as immunoregulatory mediator makes it an attractive target in the development of treatments for inflammatory and autoimmune diseases. In this study, we synthesized derivatives of IMD0354, a known inhibitor for NF‐κB, in attempt to understand the effect of...
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