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Human papillomaviruses (HPVs) target promyelocytic leukemia (PML) nuclear bodies (NBs) during infectious entry and PML protein is important for efficient transcription of incoming viral genome. However, the transcriptional down regulation was shown to be promoter‐independent in that heterologous promoters delivered by papillomavirus particles were also affected. To further investigate the role of...
The immediate environment of cells is a rich source of proteolytic enzymes due to plasma membrane and secreted proteases, and many important physiological and pathological processes take place pericellularly. Meprin metalloproteases that are membrane-bound and secreted act pericellularly to modify proteins and peptides, and there is increasing evidence that these modifications have important implications...
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