Search results for: Naomi Ariel

Items from 1 to 10 out of 10 results

chapter

Identification of Genes Involved in Yersinia pestis Virulence by Signature-tagged Mutagenesis

Yehuda Flashner, Emanuelle Mamroud, Avital Tidhar, Raphael Ber, more

Advances in Experimental Medicine and Biology > The Genus Yersinia > Evolution and Genomics > 31-33

chapter

A Rapid Method for Bacillus anthracis Genotyping

Haim Levy, Morly Fisher, Naomi Ariel, Shay Weiss, more

The Challenge of Highly Pathogenic Microorganisms > 191-198

Classification and differentiation of Bacillus anthracis isolates by genetic markers play an important role in the study of anthrax epidemiology. We have applied a PCR based method – Random Amplification of Polymorphic DNA (RAPD) to identify twenty-five B. anthracis genetic markers. These markers allowed for classification of the studied strains into five different groups. Three selected RAPD markers...

chapter

Genetic Detection of Vesicle Forming Pathogens by Arrayed Primer Extension (APEX)

Adi Beth-Din, Ofir Israeli, Ohad Shifman, Dana Stein, more

The Challenge of Highly Pathogenic Microorganisms > 173-182

The Variola virus is the causative agent of smallpox disease. Accurate identification of Variola and differential diagnosis between Variola and other vesicle forming (smallpox-like) pathogens are both technically challenging and of great importance. We compiled a list of vesicle forming pathogens that are prone to be misdiagnosed as smallpox. Some of the pathogens (members of the Orthopoxvirus genus)...

chapter

Data Mining, Bioinformatic and Immunoinformatic Analyses of Francisella tularensis Schu S4 Genome in Search for Novel Vaccine Candidates

Anat Zvi, Naomi Ariel, Avigdor Shafferman

The Challenge of Highly Pathogenic Microorganisms > 229-243

The pathogenesis mechanism and the identity of major virulence factors of the highly infectious human pathogen F. tularensis tularensis, are still poorly characterized. The restricted efficacy of the sole available vaccine (the LVS attenuated strain) and residual toxicity has motivated extensive R&D efforts directed toward the identification of alternative tularemia vaccine formulations based...

chapter

Reverse Vaccinology in Bacillus anthracis Bacillus anthracis

Avigdor Shafferman, Orit Gat, Naomi Ariel, Theodor Chitlaru, more

The Challenge of Highly Pathogenic Microorganisms > 295-306

In search for antigens which may form the basis for improved subunit or live attenuated B. anthracis vaccines, extensive genomic, proteomic and serologic analyses coupled with functional screens for surface exposed and/or secreted proteins, were carried out. The screens resulted in selection of over 50 promising novel in-vivo expressed immunogens, classified as S-Layer Homology (SLH) proteins, repeat...

article

Identification of strain specific markers in Bacillus anthracis by random amplification of polymorphic DNA

Haim Levy, Morly Fisher, Naomi Ariel, Zeev Altboum, more

FEMS Microbiology Letters > 2005 > 244 > 1 > 199-205

Classification and differentiation of Bacillus anthracis isolates by genetic markers play an important role in anthrax research. We used a PCR based method – Random Amplification of Polymorphic DNA (RAPD) – to identify genetic markers in B. anthracis strains. Twenty-five differential genetic markers were identified which divided the strains into five different groups. Three selected RAPD-markers were...

article

The Aromatic “Trapping” of the Catalytic Histidine Is Essential for Efficient Catalysis in Acetylcholinesterase ^†

Dov Barak, Dana Kaplan, Arie Ordentlich, Naomi Ariel, more

Biochemistry > 2002 > 41 > 26 > 8245 - 8252

article

Does “Butyrylization” of Acetylcholinesterase through Substitution of the Six Divergent Aromatic Amino Acids in the Active Center Gorge Generate an Enzyme Mimic of Butyrylcholinesterase? ^†

Dana Kaplan, Arie Ordentlich, Dov Barak, Naomi Ariel, more

Biochemistry > 2001 > 40 > 25 > 7433 - 7445

article

Structural modifications of the Ω loop in human acetylcholinesterase

Baruch Velan, Dov Barak, Naomi Ariel, Moshe Leitner, more

FEBS Letters > 1996 > 395 > 1 > 22-28

Conformational mobility of the surface Ω loop (Cys-69-Cys-96) in human acetylcholinesterase (HuAChE) was recently implicated in substrate accessibility to the active center and in the mechanism of allosteric modulation of enzymatic activity. We therefore generated and kinetically evaluated the following modifications or replacements in HuAChE: (a) residues at the loop ends, (b) residues involved...

article

Engineering resistance to 'aging' of phosphylated human acetylcholinesterase Role of hydrogen bond network in the active center

Arie Ordentlich, Chanoch Kronman, Dov Barak, Dana Stein, more

FEBS Letters > 1993 > 334 > 2 > 215-220

Recombinant human acetylcholinesterase (HuAChE) and selected mutants (E202Q, Y337A, E450A) were studied with respect to catalytic activity towards charged and noncharged substrates, phosphylation with organophosphorus (OP) inhibitors and subsequent aging of the OP-conjugates. Amino acid E450, unlike residues E202 and Y337, is not within interaction distance from the active center. Yet, the bimolecular...

Filter options

Publication date

Set your own date range

INFONA - science communication portal

Search results for: Naomi Ariel

Identification of Genes Involved in Yersinia pestis Virulence by Signature-tagged Mutagenesis

A Rapid Method for Bacillus anthracis Genotyping

Genetic Detection of Vesicle Forming Pathogens by Arrayed Primer Extension (APEX)

Data Mining, Bioinformatic and Immunoinformatic Analyses of Francisella tularensis Schu S4 Genome in Search for Novel Vaccine Candidates

Reverse Vaccinology in Bacillus anthracis Bacillus anthracis

Identification of strain specific markers in Bacillus anthracis by random amplification of polymorphic DNA

The Aromatic “Trapping” of the Catalytic Histidine Is Essential for Efficient Catalysis in Acetylcholinesterase ^†

Does “Butyrylization” of Acetylcholinesterase through Substitution of the Six Divergent Aromatic Amino Acids in the Active Center Gorge Generate an Enzyme Mimic of Butyrylcholinesterase? ^†

Structural modifications of the Ω loop in human acetylcholinesterase

Engineering resistance to 'aging' of phosphylated human acetylcholinesterase Role of hydrogen bond network in the active center

Filter options

Publication date

Content availability

Publication type

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Naomi Ariel

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Publication type

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options