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In the present study we show that chronic exposure to low levels of lead (Pb 2+ ) during development alters the type of N-methyl-d-aspartate receptor (NMDAR) expressed in the developing and young adult rat brain. Ifenprodil inhibition of [ 3 H]MK-801 binding to the NMDAR channel in cortical and hippocampal neuronal membranes expressed high and low affinity components. Previous...
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