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Glycosylation is one of the major posttranslational modifications of proteins. N‐glycosylation (Asn‐linked) and O‐glycosylation (Ser/Thr‐linked) are the two main forms. Abnormal O‐glycosylation is frequently observed on the surface of tumor cells, and is associated with an adverse outcome and poor prognosis in patients with cancer. O‐glycans (Tn, sTn, and T antigen) can be synthesized in the Golgi...
In this study, we typed 930 cases of nasopharyngeal carcinoma (NPC) and 1134 normal controls recruited from Hunan province, southern China for human leukocyte antigen‐A (HLA‐A) locus by sequencing exons 2–4. Very significant associations between HLA‐A*02:07, HLA‐A*11:01 and NPC were established [25.7% vs 16.18%; odds ratio, OR (95% confidence interval, CI) = 1.79 (1.54–2.09), P < 0.0001 and 21...
In this study, we investigated human leukocyte antigen (HLA)‐G*0105N and the 14 bp deletion/insertion polymorphism in exon 8 of the HLA‐G gene in 600 individuals from two southern Chinese Han populations (Hunan Han and Guangdong Han) and two northern Chinese populations (Inner Mongolia Han and Inner Mongolia Mongol), we also studied the linkage disequilibrium (LD) between HLA‐G and HLA‐A locus in...
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