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The development of cancer diagnostic imaging and treatment is a major concern worldwide. By integrating imaging and therapy into one theranostic nanoplatform for simultaneously detecting tumors, evaluating the targeting ability and timely monitoring therapeutic responses provide more opportunities for precision medicine. Among various theranostic nanosystems, a series of single‐component nanoparticles...
Taking advantage of the highly permeable vasculature and lack of lymphatic drainage in solid tumors (EPR effect), nanosized drug delivery systems or nanomedicines have been extensively explored for tumor‐targeted drug delivery. However, in most clinical cases tumors such as the early stage tumors and post‐surgery microscopic residual tumors have not yet developed such pathological EPR features, i...
Cationic polymer‐based biodelivery has attracted more and more attention in recent years because of their advantages including facilitated cellular internalization, efficient endo/lysosomal escape, and nuclear targeting. However, direct applications of cationic polymers encounter numerous problems such as cell damage, nonspecific interactions with blood components, and rapid clearance from the bloodstream...
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).This article has been regretfully retracted at the request of the authors due to mistakes which occurred during the figure preparation. Although the authors published a corrigendum about these mistakes (Cancer Lett. 2016 Aug 1. pii: S0304-3835(16)30443-8), they now feel...
Background Lung cancer in nonsmokers tends to be driven by a single somatic mutation or a gene fusion. KIF5B-RET fusion is an oncogene identified in non-small cell lung cancers. In this study, we verified the oncogenic activity of KIF5B-RET fusion and investigated how KIF5B-RET activates the specific signaling pathways for cellular transformation. We aimed to provide a basis for the further development...
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