Search results for: J. Christie

Items from 1 to 20 out of 166 results

article

Identifying potential cases of eating disorders in an acute medical hospital

Vivien Hui In Cheung, Lauren J. Christie, Terri Maister, Devlin Higgins, more

International Journal of Eating Disorders > 57 > 8 > 1707 - 1715

Objective To identify patients presenting to an acute medical hospital with common signs and symptoms that occur in people with eating disorders (EDs), and determine by retrospective file audit if these are diagnosed cases of an ED. Method The investigators screened electronic medical records of people 16 years and older for common signs and symptoms of an ED such as hypokalemia, in patients presenting...

article

Contributions of F‐specific subunits to the F plasmid‐encoded type IV secretion system and F pilus

Kouhei Kishida, Rachel E. Bosserman, Laith Harb, Pratick Khara, more

Molecular Microbiology > 117 > 5 > 1275 - 1290

F plasmids circulate widely among the Enterobacteriaceae through encoded type IV secretion systems (T4SS_Fs). Assembly of T4SS_Fs and associated F pili requires 10 VirB/VirD4‐like Tra subunits and eight or more F‐specific subunits. Recently, we presented evidence using in situ cryoelectron tomography (cryoET) that T4SS_Fs undergo structural transitions when activated for pilus production, and that assembled...

article

VP10.13: Fetal ocular coloboma and cleft lip and palate with structurally normal brain: a case report

J. Brown, R. Nayyar, P. Shetty, J. Christie

Ultrasound in Obstetrics & Gynecology > 58 > S1 > 134 - 134

article

Type IV secretion systems: Advances in structure, function, and activation

Tiago R. D. Costa, Laith Harb, Pratick Khara, Lanying Zeng, more

Molecular Microbiology > 115 > 3 > 436 - 452

Bacterial type IV secretion systems (T4SSs) are a functionally diverse translocation superfamily. They consist mainly of two large subfamilies: (i) conjugation systems that mediate interbacterial DNA transfer and (ii) effector translocators that deliver effector macromolecules into prokaryotic or eukaryotic cells. A few other T4SSs export DNA or proteins to the milieu, or import exogenous DNA. The...

article

OC18.08: Genotype‐phenotype correlation of the fetus with ganglionic eminence abnormality

S. Goergen, J. Taylor, J. Christie, M. Teoh, more

Ultrasound in Obstetrics & Gynecology > 56 > S1 > 52 - 52

article

The TraK accessory factor activates substrate transfer through the pKM101 type IV secretion system independently of its role in relaxosome assembly

Yang Grace Li, Peter J. Christie

Molecular Microbiology > 114 > 2 > 214 - 229

A large subfamily of the type IV secretion systems (T4SSs), termed the conjugation systems, transmit mobile genetic elements (MGEs) among many bacterial species. In the initiating steps of conjugative transfer, DNA transfer and replication (Dtr) proteins assemble at the origin‐of‐transfer (oriT) sequence as the relaxosome, which nicks the DNA strand destined for transfer and couples the nicked substrate...

article

Morphine‐induced respiratory depression is independent of β‐arrestin2 signalling

Andrea Kliewer, Alexander Gillis, Rob Hill, Frank Schmiedel, more

British Journal of Pharmacology > 177 > 13 > 2923 - 2931

Background and Purpose GPCRs can signal through both G proteins and β‐arrestin2. For the μ‐opioid receptor, early experimental evidence from a single study suggested that G protein signalling mediates analgesia, whereas β‐arrestin2 signalling mediates respiratory depression and constipation. Consequently, for more than a decade, much research effort has been focused on developing biased μ‐opioid...

article

EP17.05: Prenatal diagnosis of unilateral isolated persistent hyperplastic primary vitreous

D. Paoletti, M. Robertson, T. Sandercoe, J. Christie, more

Ultrasound in Obstetrics & Gynecology > 54 > S1 > 335 - 335

article

The Rich Tapestry of Bacterial Protein Translocation Systems

Peter J. Christie

The Protein Journal > 2019 > 38 > 4 > 389-408

The translocation of proteins across membranes is a fundamental cellular function. Bacteria have evolved a striking array of pathways for delivering proteins into or across cytoplasmic membranes and, when present, outer membranes. Translocated proteins can form part of the membrane landscape, reside in the periplasmic space situated between the inner and outer membranes of Gram-negative bacteria,...

article

Constraint‐induced movement therapy for upper limb recovery in adult neurorehabilitation: An international survey of current knowledge and experience

Lauren J. Christie, Annie McCluskey, Meryl Lovarini

Australian Occupational Therapy Journal > 66 > 3 > 401 - 412

Introduction Constraint‐induced movement therapy (CIMT) is an effective intervention for upper limb recovery following stroke and traumatic brain injury. Despite strong evidence, the use of CIMT in practice is limited. The aim of this study was to investigate clinician knowledge and experience of delivering CIMT protocols internationally in neurorehabilitation. Methods A cross‐sectional survey...

article

The effects of inpatient music therapy on self-reported symptoms at an academic cancer center: a preliminary report

Gabriel Lopez, Aimee J. Christie, Catherine Powers-James, Mi Sun Bae, more

Supportive Care in Cancer > 2019 > 27 > 11 > 4207-4212

Purpose Music therapy has shown benefits for reducing distress in individuals with cancer. We explore the effects of music therapy on self-reported symptoms of patients receiving inpatient care at a comprehensive cancer center. Methods Music therapy was available as part of an inpatient integrative oncology consultation service; we examined interventions and symptoms for consecutive patients treated...

article

Two pKM101‐encoded proteins, the pilus‐tip protein TraC and Pep, assemble on the Escherichia coli cell surface as adhesins required for efficient conjugative DNA transfer

Christian González‐Rivera, Pratick Khara, Dominik Awad, Roosheel Patel, more

Molecular Microbiology > 111 > 1 > 96 - 117

Mobile genetic elements (MGEs) encode type IV secretion systems (T4SSs) known as conjugation machines for their transmission between bacterial cells. Conjugation machines are composed of an envelope‐spanning translocation channel, and those functioning in Gram‐negative species additionally elaborate an extracellular pilus to initiate donor‐recipient cell contacts. We report that pKM101, a self‐transmissible...

article

PrgB promotes aggregation, biofilm formation, and conjugation through DNA binding and compaction

Andreas Schmitt, Kai Jiang, Martha I. Camacho, Venkateswara Rao Jonna, more

Molecular Microbiology > 109 > 3 > 291 - 305

Gram‐positive bacteria deploy type IV secretion systems (T4SSs) to facilitate horizontal gene transfer. The T4SSs of Gram‐positive bacteria rely on surface adhesins as opposed to conjugative pili to facilitate mating. Enterococcus faecalis PrgB is a surface adhesin that promotes mating pair formation and robust biofilm development in an extracellular DNA (eDNA) dependent manner. Here, we report the...

article

Salience drives overt selection of two equally relevant visual targets

Gregory J. Christie, Thomas M. Spalek, John J. McDonald

Attention, Perception, & Psychophysics > 2018 > 80 > 6 > 1342-1349

In the present study, we investigated whether salience determines the sequence of selection when participants search for two equally relevant visual targets. To do this, attentional selection was tracked overtly as observers inspected two items of differing physical salience: one a highly salient color singleton, and the other a less salient shape singleton. Participants were instructed to make natural...

article

Activity of novel lipid glycine transporter inhibitors on synaptic signalling in the dorsal horn of the spinal cord

Bryony L Winters, Tristan Rawling, Robert J Vandenberg, Macdonald J Christie, more

British Journal of Pharmacology > 175 > 12 > 2337 - 2347

Background and Purpose Inhibitory neurotransmission plays an important role in controlling excitability within nociceptive circuits of the spinal cord dorsal horn. Loss of inhibitory signalling is thought to contribute to the development of pathological pain. Preclinical studies suggest that increasing inhibitory glycinergic signalling is a good therapeutic strategy for treating pain. One approach...

article

Substance P and dopamine interact to modulate the distribution of delta‐opioid receptors on cholinergic interneurons in the striatum

Emily Heath, Billy Chieng, Macdonald J. Christie, Bernard W. Balleine

European Journal of Neuroscience > 47 > 10 > 1159 - 1173

It has been recently demonstrated that predictive learning induces a persistent accumulation of delta‐opioid receptors (DOPrs) at the somatic membrane of cholinergic interneurons (CINs) in the nucleus accumbens shell (Nac‐S). This accumulation is required for predictive learning to influence subsequent choice between goal‐directed actions. The current experiments investigated the local neurochemical...

article

Berichtigung: Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter

Andreas Brust, Ching‐I. A. Wang, Norelle L. Daly, Joe Kennerly, more

Angewandte Chemie > 130 > 19 > 5299 - 5299

article

Corrigendum: Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter

Andreas Brust, Ching‐I. A. Wang, Norelle L. Daly, Joe Kennerly, more

Angewandte Chemie International Edition > 57 > 19 > 5203 - 5203

article

Type IV secretion in Gram‐negative and Gram‐positive bacteria

Elisabeth Grohmann, Peter J. Christie, Gabriel Waksman, Steffen Backert

Molecular Microbiology > 107 > 4 > 455 - 471

Type IV secretion systems (T4SSs) are versatile multiprotein nanomachines spanning the entire cell envelope in Gram‐negative and Gram‐positive bacteria. They play important roles through the contact‐dependent secretion of effector molecules into eukaryotic hosts and conjugative transfer of mobile DNA elements as well as contact‐independent exchange of DNA with the extracellular milieu. In the last...

article

Midterm Survivorship After Revision Total Hip Arthroplasty With a Custom Triflange Acetabular Component

Brian P. Gladnick, Keith A. Fehring, Susan M. Odum, Michael J. Christie, more

The Journal of Arthroplasty > 2018 > 33 > 2 > 500-504

Custom triflange acetabular components are being increasingly used for the reconstruction of Paprosky type IIIB acetabular defects. However, midterm survivorship data are lacking.We queried the prospective registries at 2 high-volume revision centers for patients who had undergone revision total hip arthroplasty using a custom triflange component between 2000 and 2011. We identified 73 patients with...

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Search results for: J. Christie

Identifying potential cases of eating disorders in an acute medical hospital

Contributions of F‐specific subunits to the F plasmid‐encoded type IV secretion system and F pilus

VP10.13: Fetal ocular coloboma and cleft lip and palate with structurally normal brain: a case report

Type IV secretion systems: Advances in structure, function, and activation

OC18.08: Genotype‐phenotype correlation of the fetus with ganglionic eminence abnormality

The TraK accessory factor activates substrate transfer through the pKM101 type IV secretion system independently of its role in relaxosome assembly

Morphine‐induced respiratory depression is independent of β‐arrestin2 signalling

EP17.05: Prenatal diagnosis of unilateral isolated persistent hyperplastic primary vitreous

The Rich Tapestry of Bacterial Protein Translocation Systems

Constraint‐induced movement therapy for upper limb recovery in adult neurorehabilitation: An international survey of current knowledge and experience

The effects of inpatient music therapy on self-reported symptoms at an academic cancer center: a preliminary report

Two pKM101‐encoded proteins, the pilus‐tip protein TraC and Pep, assemble on the Escherichia coli cell surface as adhesins required for efficient conjugative DNA transfer

PrgB promotes aggregation, biofilm formation, and conjugation through DNA binding and compaction

Salience drives overt selection of two equally relevant visual targets

Activity of novel lipid glycine transporter inhibitors on synaptic signalling in the dorsal horn of the spinal cord

Substance P and dopamine interact to modulate the distribution of delta‐opioid receptors on cholinergic interneurons in the striatum

Berichtigung: Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter

Corrigendum: Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter

Type IV secretion in Gram‐negative and Gram‐positive bacteria

Midterm Survivorship After Revision Total Hip Arthroplasty With a Custom Triflange Acetabular Component

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