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Key points
Brief dopamine events are critical actors of reward‐mediated learning in the striatum; the intracellular cAMP–protein kinase A (PKA) response of striatal medium spiny neurons to such events was studied dynamically using a combination of biosensor imaging in mouse brain slices and in silico simulations.
Both D1 and D2 medium spiny neurons can sense brief dopamine transients in the sub‐micromolar...