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Dysfunction of mitochondrial activity is often associated with the onset and progress of neurodegenerative diseases. Membrane depolarization induced by Na+ influx increases intracellular Ca2+ levels in neurons, which upregulates mitochondrial activity. However, overlimit of Na+ influx and its prolonged retention ultimately cause excitotoxicity leading to neuronal cell death. To return the membrane...
We found that a female infant presenting with left bundle branch block and left ventricular noncompaction carries uninvestigated gene mutations HCN4(G811E), SCN5A(L1988R), DMD(S2384Y), and EMD(R203H). Here, we explored the possible pathogenicity of HCN4(G811E), which results in a G811E substitution in hyperpolarization-activated cyclic nucleotide-gated channel 4, the main subunit of the cardiac pacemaker...
We report on single electron transistor (SET) operation in single-walled carbon nanotubes (SWNTs) to estimate the length of ballistic conduction in laser-synthesized SWNTs. The devices were fabricated by an alternating current-aligned method and the SWNTs were side-contacted to the electrodes. At 5K, Coulomb oscillation and Coulomb diamonds were observed and the Coulomb island length, i.e., the ballistic...
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