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Nuclear receptor peroxisome proliferator‐activated receptor γ (PPAR‐γ) activation can prevent immunoinflammatory disorders and diabetes. B cells play protective roles during inflammation as well. However, the roles of endogenous PPAR‐γ in the regulatory properties of B cells to relieve inflammation remain unknown. Here, we developed B‐cell‐specific PPAR‐γ knockout (B‐PPAR‐γ−/−) mice and found that...
Certain B cells termed as “regulatory B cells” (Bregs) can suppress the ongoing immune responses and a splenic CD5+CD1dhi Breg subset identified earlier was shown to exert its regulatory functions through secretion of IL-10. Though FasL expression is an alternative mechanism of immune suppression used by B cells, little is known about the FasL expressing CD5+CD1dhi Bregs. In this study, we isolated...
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