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Functional disorders of the thyroid remain a global challenge and have profound impacts on human health. Serving as the barometer for thyroid function, thyroid‐stimulating hormone (TSH) is considered the single most useful test of thyroid function. However, the prevailing TSH immunoassays rely on two types of antibodies in a sandwich format. The requirement of repeated incubation and washing further...
While immunoassays are pivotal to medical diagnosis and bioanalytical chemistry, the current landscape of public health has catalyzed an important shift in the requirements of immunoassays that demand innovative solutions. For example, rapid, label‐free, and low‐cost screening of a given analyte is required to inform the best countermeasures to combat infectious diseases in a timely manner. Yet, the...
Small molecules play a pivotal role in regulating physiological processes and serve as biomarkers to uncover pathological conditions and the effects of therapeutic treatments. However, it remains a significant challenge to detect small molecules given the size as compared to macromolecules. Recently, the newly emerging plasmonic immunoassays based on surface‐enhanced Raman scattering (SERS) offer...
Enhancing light‐matter interactions is fundamental to the advancement of nanophotonics and optoelectronics. Yet, light diffraction on dielectric platforms and energy loss on plasmonic metallic systems present an undesirable trade‐off between coherent energy exchange and incoherent energy damping. Through judicious structural design, both light confinement and energy loss issues could be potentially...
Background Although identification of the target mRNAs of micro RNAs (miRNAs) is essential to understanding their function, the low complementarity between miRNAs and their target mRNAs has complicated this process. In this study, we sought to identify miRNAs which reduce the expression of the transcription factor Zeb-2, a transcriptional repressor of E-cadherin which is known to be down regulated...
Ten-fold-like magnetic anisotropy is reproducibly observed in electrical conductivity of Al 71 Pd 21 Mn 8 icosahedral quasicrystal. The voltage V is measured, where the current I is along a five-fold axis of the sample and is perpendicular to the magnetic field H. The voltage difference ΔV=V(+I)+V(-I) has angle dependences at H=30~80 kOe and the temperature T=2~8...
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