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Increased stiffness of the Schlemm's canal (SC) endothelium in the aqueous humor outflow pathways has been associated with elevated intraocular pressure (IOP) in glaucoma. Novel treatments that relax this endothelium, such as actin depolymerizers and rho kinase inhibitors, are in development. Unfortunately, these treatments have undesirable off‐target effects and a lower than desired potency. To address...
In article 2000078, Alison Patteson et al. review the various functions of filamentous and non‐filamentous vimentin. While the mechanical and intracellular roles of vimentin – such as providing protection of the nucleus and elasticity to the cytoskeleton – are well documented, recent studies point towards additional, non‐mechanical functions for vimentin. These functions include signaling roles in...
Intermediate filaments (IFs) formed by vimentin are less understood than their cytoskeletal partners, microtubules and F‐actin, but the unique physical properties of IFs, especially their resistance to large deformations, initially suggest a mechanical function. Indeed, vimentin IFs help regulate cell mechanics and contractility, and in crowded 3D environments they protect the nucleus during cell...
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