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Eph receptors and ephrin ligands have been shown to be differentially expressed on leucocytes. Here, we show that one member of the ephrin‐B subfamily of ephrins, ephrin‐B3, specifically binds to B lymphocytes in blood. No binding was observed to T lymphocytes or monocytes. The ephrin‐B3 binding receptor on B lymphocytes is so far not identified, but our results here indicate that ephrin‐B3 binds...