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Skin fibrosis is a chronic debilitating feature of several skin diseases that lead to characteristic increases in dermal fibroblast proliferation and collagen deposition through upregulation in components of the transforming growth factor beta (TGF‐B)/SMAD pathway. In contrast to ultraviolet phototherapy, high‐fluence light‐emitting diode‐generated red light (HF‐LED‐RL, 633 ± 15 nm) is a safe, economic...
PURPOSEOur previous studies showed that NF‐κB2/p52 is involved in the castration‐resistant growth of the androgen‐sensitive LNCaP prostate cancer cells. The role of NF‐κB2/p52 in lymphomagenesis has been studied extensively, but its target genes in other cancers remain unknown. In order to identify genes potentially regulated by p52 in prostate cancer cells, we performed a genome‐wide microarray analysis...
Introduction: In order to study breast cancer progression, we utilized two related transgenic mouse models of mammary carcinoma (termed Met and Db). Met tumors are highly invasive with 100% pulmonary metastases, whereas Db tumors, possessing a mutation abrogating PI3K recruitment, exhibit fewer metastases without signs of invasion. The purpose of our study was to determine the role of PI3K effectors...
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