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DOI: 10.1002/pmic.201500400
Type 1‐metabotropic glutamate receptors in the brain control long term synaptic plasticity and are considered important drug targets in autism spectrum disorders. Using interaction proteomics, a specific complex of mGluR5‐mGluR1 (isoform b) heterodimer was elucidated to occur at synaptic sites. For more details, see the article by Nikhil J. Pandya et al. on page 2698. (Cover...
The group 1 metabotropic glutamate receptors 1 and 5 (mGluR1/5) have been implicated in mechanisms of synaptic plasticity and may serve as potential therapeutic targets in autism spectrum disorders. The interactome of group 1 mGluRs has remained largely unresolved. Using a knockout‐controlled interaction proteomics strategy we examined the mGluR5 protein complex in two brain regions, hippocampus and...
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