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Although antibodies are considered critical for malaria protection, little is known about the mechanisms/factors that maintain humoral immunity, especially regarding the induction and maintenance of memory B cells over time. In Brazilian endemic areas, this is the first time that the profile of antibody responses and the occurrence of antigen‐specific memory B cells (MBC) against P vivax were investigated...
Plasmodium falciparum‐specific antibodies tend to be short‐lived, but their cognate memory B cells (MBCs) circulate in the peripheral blood of exposed subjects for several months or years after the last infection. However, the time course of antigen‐specific antibodies and B‐cell responses to the relatively neglected parasite Plasmodium vivax remains largely unexplored. Here, we showed that uncomplicated...
The geographic distribution of the Plasmodium and intestinal parasites are overlapped over the world, therefore malaria co-infection with intestinal parasites are common in tropical regions of the planet. The immune response against Plasmodium is characterized by a Th1 profile. On the other hand, helminth infections induce a strong immunoregulatory and Th2 response that can inhibit the inflammatory...
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