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Augmented renal clearance (ARC) has been reported in approximately 30–65% of patients in the intensive care unit (ICU) despite the presence of a normal serum creatinine concentration. In certain ICU patient populations (e.g., patients with sepsis or trauma), the incidence increases to roughly 50–85%. Risk factors for ARC include the following: age younger than 50–55 years, male sex, higher diastolic...