Search results for: Pierre Leblond

Items from 1 to 20 out of 55 results

article

Retrospective experience of children with relapsed brain tumors treated with oral combination of axitinib and metronomic etoposide

Caroline Donzé, Gabriel Revon‐Rivière, Morgane Pondrom, Arnauld Verschuur, more

Pediatric Blood & Cancer > 71 > 8 > n/a - n/a

Metronomic chemotherapy‐based combinations have received interest for relapsed/refractory malignancies. Preclinical and clinical studies showed activity of metronomic etoposide and axitinib. We report our retrospective experience in six children treated with axitinib and metronomic etoposide for refractory/relapsed brain tumors as an “off‐label” combination. Three patients with medulloblastoma experienced...

article

Pharmacokinetics of oral vinorelbine in French children with recurrent or progressive primary low‐grade glioma

Mourad Hamimed, Florence Gattacceca, Nicolas André, Emmanuelle Tresch‐Bruneel, more

British Journal of Clinical Pharmacology > 88 > 5 > 2096 - 2117

Aims There is a crucial need for pharmacokinetic (PK) data on oral vinorelbine (VNR) in the paediatric population. The aim of this work was to assess the PK profile of orally administered VNR in children with recurrent/progressive primary low‐grade glioma (LGG). Methods A multicentre, open‐label, single‐arm intervention phase II study was conducted. Patients, aged between 6 and 18 years, with histologically...

article

NTRK2 gene fusion and resistance mutation: Seventeen‐year course of a paediatric glioma

Marc Barritault, Delphine Poncet, David Meyronet, Alexandre Vasiljevic, more

Pediatric Blood & Cancer > 68 > 9 > n/a - n/a

article

Nephrogenic rests located inside a retroperitoneal colonic duplication and their evolution into a Wilms tumor

Cécile Picard, Pierre Leblond, Jean‐Pierre Pracros, Grégoire Schneider, more

Pediatric Blood & Cancer > 67 > 11 > n/a - n/a

article

Exploring heterogeneity of adrenal cortical tumors in children: The French pediatric rare tumor group (Fracture) experience

Cécile Picard, Cécile Faure‐Conter, Pierre Leblond, Laurence Brugières, more

Pediatric Blood & Cancer > 67 > 2 > n/a - n/a

Introduction Pediatric adrenal cortical tumors are characterized by a wide spectrum of behavior. Questions remain regarding intermediate disease stages with isolated tumor rupture or relapse. Objectives To describe clinical characteristics, treatment strategy, and outcome of patients depending on disease stage, tumor rupture, or in case of a refractory tumor, to discuss optimal management. Material...

article

Identification of prognostic markers in diffuse midline gliomas H3K27M‐mutant

Charlotte Dufour, Romain Perbet, Pierre Leblond, Romain Vasseur, more

Brain Pathology > 30 > 1 > 179 - 190

Pediatric diffuse midline gliomas are devastating diseases. Among them, diffuse midline gliomas H3K27M‐mutant are associated with worse prognosis. However, recent studies have highlighted significant differences in clinical behavior and biological alterations within this specific subgroup. In this context, simple markers are needed to refine the prognosis of diffuse midline gliomas H3K27M‐mutant and...

article

Phase II study of temozolomide and topotecan (TOTEM) in children with relapsed or refractory extracranial and central nervous system tumors including medulloblastoma with post hoc Bayesian analysis: A European ITCC study

Gwénaël Le Teuff, Alicia Castaneda‐Heredia, Christelle Dufour, Timothy Jaspan, more

Pediatric Blood & Cancer > 67 > 1 > n/a - n/a

Aim To assess objective response after two cycles of temozolomide and topotecan (TOTEM) in children with refractory or relapsed miscellaneous extracranial solid and central nervous system (CNS) tumors, including medulloblastoma and primitive neuroectodermal tumors (PNET). Procedure Multicenter, nonrandomized, phase 2 basket trial including children with solid tumors, completed by a one‐stage design...

article

Family history of cancer and the risk of childhood brain tumors: a pooled analysis of the ESCALE and ESTELLE studies (SFCE)

Nicolas Vidart d’Egurbide Bagazgoïtia, Helen D. Bailey, Laurent Orsi, Léa Guerrini-Rousseau, more

Cancer Causes & Control > 2019 > 30 > 10 > 1075-1085

Purpose Although some specific genetic syndromes such as neurofibromatosis (NF) have been identified as risk factor of childhood brain tumors (CBT), the potential role of inherited susceptibility in CBT has yet to be elucidated. Methods To further investigate this, we conducted a pooled analysis of two nationwide case–control studies ESCALE and ESTELLE. The mothers of 509 CBT cases and 3,102 controls...

article

SFCE METRO‐01 four‐drug metronomic regimen phase II trial for pediatric extracranial tumor

Marie‐Amélie Heng‐Maillard, Arnauld Verschuur, Audrey Aschero, Alexia Dabadie, more

Pediatric Blood & Cancer > 66 > 7 > n/a - n/a

Objective To investigate the antitumor activity of a four‐drug metronomic chemotherapy (MC) regimen in relapsed/progressing pediatric extracranial solid tumors (EST). The primary objective was clinical benefit (complete response /partial response/stable disease [SD]) after two cycles of therapy (four months). Methods Patients aged ≥4 to 25 years with progressing EST and adequate organ function...

article

A Multiplex Quantitative Reverse Transcription Polymerase Chain Reaction Assay for the Detection of KIAA1549–BRAF Fusion Transcripts in Formalin-Fixed Paraffin-Embedded Pilocytic Astrocytomas

David Bret, Valentin Chappuis, Delphine Poncet, François Ducray, more

Molecular Diagnosis & Therapy > 2019 > 23 > 4 > 537-545

Background and objective Genomic duplications and fusion involving BRAF and KIAA1549 that create fusion proteins with constitutive B-RAF kinase activity are a hallmark of pilocytic astrocytomas (PAs). The detection of KIAA1549–BRAF fusion transcripts is of paramount importance to classify these tumors and to identify patients who could benefit from BRAF inhibitors. In a clinical setting, the available...

article

Bacterial NHEJ: a never ending story

Claire Bertrand, Annabelle Thibessard, Claude Bruand, François Lecointe, more

Molecular Microbiology > 111 > 5 > 1139 - 1151

Double‐strand breaks (DSBs) are the most detrimental DNA damage encountered by bacterial cells. DBSs can be repaired by homologous recombination thanks to the availability of an intact DNA template or by Non‐Homologous End Joining (NHEJ) when no intact template is available. Bacterial NHEJ is performed by sets of proteins of growing complexity from Bacillus subtilis and Mycobacterium tuberculosis ...

article

An aminoacylase activity from Streptomyces ambofaciens catalyzes the acylation of lysine on α‐position and peptides on N‐terminal position

Léna Dettori, Florent Ferrari, Xavier Framboisier, Cédric Paris, more

Engineering in Life Sciences > 18 > 8 > 589 - 599

The presence of aminoacylase activities was investigated in a crude extract of Streptomyces ambofaciens ATCC23877. First activities catalyzing the hydrolysis of N‐α or ε‐acetyl‐L‐lysine were identified. Furthermore, the acylation of lysine and different peptides was studied and compared with results obtained with lipase B of Candida antarctica (CALB). Different regioselectivities were demonstrated...

article

The extraordinary challenge of treating patients with congenital rhabdoid tumors—a collaborative European effort

Karolina Nemes, Nathalie Clément, Denis Kachanov, Susanne Bens, more

Pediatric Blood & Cancer > 65 > 6 > n/a - n/a

Background Congenital rhabdoid tumors are rare and highly aggressive malignancies. In general, patients are considered to be incurable and are often treated using an exclusive, primarily palliative approach. Methods A prospective and retrospective collection of 42 patients from the European Rhabdoid Registry (EU‐RHAB), France and Moscow (2006–2016) diagnosed within the first 28 days of life was...

article

Childhood brain tumours, early infections and immune stimulation: A pooled analysis of the ESCALE and ESTELLE case-control studies (SFCE, France)

Judith E. Lupatsch, Helen D. Bailey, Brigitte Lacour, Christelle Dufour, more

Cancer Epidemiology > 2018 > 52 > C > 1-9

Few studies have investigated whether early infections and factors potentially related to early immune stimulation might be involved in the aetiology of childhood brain tumours (CBT). In this study, we investigated the associations between CBT with early day-care attendance, history of early common infections, atopic conditions (asthma/wheezing, eczema, allergic rhinitis), early farm residence/visits...

article

Maternal residential pesticide use during pregnancy and risk of malignant childhood brain tumors: A pooled analysis of the ESCALE and ESTELLE studies (SFCE)

Nicolas Vidart d'Egurbide Bagazgoïtia, Helen D. Bailey, Laurent Orsi, Brigitte Lacour, more

International Journal of Cancer > 142 > 3 > 489 - 497

Some previous epidemiological studies have suggested that pesticide exposure during pregnancy may have a possible role in the development of childhood brain tumors (CBT). We pooled data from two French national population‐based, case–control studies to investigate the association between maternal residential use of pesticides during pregnancy and the risk of CBT. The mothers of 437 CBT cases and 3,102...

article

Parental smoking, maternal alcohol, coffee and tea consumption and the risk of childhood brain tumours: the ESTELLE and ESCALE studies (SFCE, France)

Helen D. Bailey, Brigitte Lacour, Léa Guerrini-Rousseau, Anne-Isabelle Bertozzi, more

Cancer Causes & Control > 2017 > 28 > 7 > 719-732

Purpose To investigate whether parental smoking around the time of pregnancy or maternal consumption of beverages (alcohol, coffee, or tea) during pregnancy were associated with the risk of CBT. Methods We pooled data from two French national population-based case–control studies with similar designs conducted in 2003–2004 and 2010–2011. The mothers of 510 CBT cases (directly recruited from the...

article

Outcome and prognostic factors in high‐risk childhood adrenocortical carcinomas: A report from the European Cooperative Study Group on Pediatric Rare Tumors (EXPeRT)

Giovanni Cecchetto, Alba Ganarin, Ewa Bien, Peter Vorwerk, more

Pediatric Blood & Cancer > 64 > 6 > n/a - n/a

Objectives The aim of this retrospective international analysis was to evaluate the role of risk factors in pediatric patients with adrenocortical carcinoma (ACC) observed in European countries (2000–2013) in an attempt to identify factors associated with poor prognosis. Procedures Data were retrieved from databases of Germany, France, Poland, and Italy, which form the European Cooperative Study...

article

Factors related to pregnancy and birth and the risk of childhood brain tumours: The ESTELLE and ESCALE studies (SFCE, France)

Helen D. Bailey, Paula Rios, Brigitte Lacour, Léa Guerrini‐Rousseau, more

International Journal of Cancer > 140 > 8 > 1757 - 1769

Little is known of the causes of childhood brain tumors (CBT). The aims of this study were to investigate whether extremes of birth weight were associated with increased risk of CBT and whether maternal preconceptional folic acid supplementation or breastfeeding reduced the risk. In addition, other maternal characteristics and birth related factors were also investigated. We pooled data from two French...

article

Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease

Sophie E. M. Veldhuijzen van Zanten, Joshua Baugh, Brooklyn Chaney, Dennis Jongh, more

Journal of Neuro-Oncology > 2017 > 132 > 2 > 255-266

Diffuse intrinsic pontine glioma (DIPG) is a rare and deadly childhood malignancy. After 40 years of mostly single-center, often non-randomized trials with variable patient inclusions, there has been no improvement in survival. It is therefore time for international collaboration in DIPG research, to provide new hope for children, parents and medical professionals fighting DIPG. In a first step towards...

article

Implication of RuvABC and RecG in homologous recombination in Streptomyces ambofaciens

Grégory Hoff, Claire Bertrand, Emilie Piotrowski, Annabelle Thibessard, more

Research in Microbiology > 2017 > 168 > 1 > 26-35

Most bacterial organisms rely on homologous recombination to repair DNA double-strand breaks and for the post-replicative repair of DNA single-strand gaps. Homologous recombination can be divided into three steps: (i) a pre-synaptic step in which the DNA 3′-OH ends are processed, (ii) a recA-dependent synaptic step allowing the invasion of an intact copy and the formation of Holliday junctions, and...

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INFONA - science communication portal

Search results for: Pierre Leblond

Retrospective experience of children with relapsed brain tumors treated with oral combination of axitinib and metronomic etoposide

Pharmacokinetics of oral vinorelbine in French children with recurrent or progressive primary low‐grade glioma

NTRK2 gene fusion and resistance mutation: Seventeen‐year course of a paediatric glioma

Nephrogenic rests located inside a retroperitoneal colonic duplication and their evolution into a Wilms tumor

Exploring heterogeneity of adrenal cortical tumors in children: The French pediatric rare tumor group (Fracture) experience

Identification of prognostic markers in diffuse midline gliomas H3K27M‐mutant

Phase II study of temozolomide and topotecan (TOTEM) in children with relapsed or refractory extracranial and central nervous system tumors including medulloblastoma with post hoc Bayesian analysis: A European ITCC study

Family history of cancer and the risk of childhood brain tumors: a pooled analysis of the ESCALE and ESTELLE studies (SFCE)

SFCE METRO‐01 four‐drug metronomic regimen phase II trial for pediatric extracranial tumor

A Multiplex Quantitative Reverse Transcription Polymerase Chain Reaction Assay for the Detection of KIAA1549–BRAF Fusion Transcripts in Formalin-Fixed Paraffin-Embedded Pilocytic Astrocytomas

Bacterial NHEJ: a never ending story

An aminoacylase activity from Streptomyces ambofaciens catalyzes the acylation of lysine on α‐position and peptides on N‐terminal position

The extraordinary challenge of treating patients with congenital rhabdoid tumors—a collaborative European effort

Childhood brain tumours, early infections and immune stimulation: A pooled analysis of the ESCALE and ESTELLE case-control studies (SFCE, France)

Maternal residential pesticide use during pregnancy and risk of malignant childhood brain tumors: A pooled analysis of the ESCALE and ESTELLE studies (SFCE)

Parental smoking, maternal alcohol, coffee and tea consumption and the risk of childhood brain tumours: the ESTELLE and ESCALE studies (SFCE, France)

Outcome and prognostic factors in high‐risk childhood adrenocortical carcinomas: A report from the European Cooperative Study Group on Pediatric Rare Tumors (EXPeRT)

Factors related to pregnancy and birth and the risk of childhood brain tumours: The ESTELLE and ESCALE studies (SFCE, France)

Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease

Implication of RuvABC and RecG in homologous recombination in Streptomyces ambofaciens

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