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SETDB1 is a histone lysine methyltransferase that has critical roles in cancers. However, its potential role in gastric cancer (GC) remains obscure. Here, we mainly investigate the clinical significance and the possible role of SETDB1 in GC. We find that SETDB1 expression is upregulated in GC tissues and its high‐level expression was a predictor of poor prognosis in patients. Overexpression of SETDB1...
Epigenetic mechanisms play a key role in gastrointestinal cancer (GIC) development and progression, and most studies have been focused on aberrant DNA methylation and histone modifying enzymes. However, the histone H3–H4 chaperone ASF1A is an important factor regulating chromatin assembling and gene transcription, while it is currently unclear whether ASF1A is involved in cancer pathogenesis. The...
•TERT promoter mutations activating telomerase occur in certain types of cancer. •The mutations were not detected in cancer tissue from 200 gastric cancer patients. •TERT promoter mutation is not a mechanism for telomerase activation in gastric cancer.
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