The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Objective
Oral tongue squamous cell carcinoma (OTSCC) frequently harbors non‐functional p53 and depends on G2/M checkpoint mediated by WEE1. WEE1 suppression has been identified as a promising anti‐tumor strategy. This study investigated the capacity of WEE1 kinase inhibitor (MK‐1775) and its underlying mechanisms in enhancing radiation responses of OTSCC cells in vitro.
Materials and methods
WEE1...