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Background
We reported that high‐fat diet (HFD)‐induced metabolic syndrome (MetS) exacerbates lipopolysaccharide (LPS)‐stimulated periodontitis and palmitate, the major saturated fatty acid in the HFD, amplified LPS‐stimulated gene expression in vitro. As CD36 is a major receptor for fatty acids, we investigated periodontal CD36 expression in mice with periodontitis and MetS, and the role of CD36...
BackgroundThis study was conducted to assess whether statin intake is associated with clinical parameters of periodontitis and matrix metalloproteinase (MMP) levels in gingival crevicular fluid (GCF) of non‐diabetic and diabetic patients.
MethodsWe first determined the effect of simvastatin on MMP expression in mononuclear cells. We then recruited 117 non‐diabetic and diabetic patients, who all had...
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