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Novel molecularly targeted agents (MTAs) have emerged as valuable alternatives or complements to traditional cytotoxic agents in the treatment of cancer. Clinicians are combining cytotoxic agents with MTAs in a single trial to achieve treatment synergism and better outcomes for patients. An important feature of such combinational trials is that, unlike the efficacy of the cytotoxic agent, that of...
The aim of phase I combination dose‐finding studies in oncology is to estimate one or several maximum tolerated doses (MTDs) from a set of available dose levels of two or more agents. Combining several agents can indeed increase the overall anti‐tumor action but at the same time also increase the toxicity. It is, however, unreasonable to assume the same dose–toxicity relationship for the combination...
ObjectivesTo determine the role of Msx2 in craniofacial morphology and growth, we used a mouse model and performed a quantitative morphological characterization of the Msx2−/− and the Msx2+/− phenotype using a 2D cephalometric analysis applied on micrographs.
Materials and MethodsForty‐four three‐and‐a‐half‐month‐old female CD1 mice were divided into the following three groups: Msx2+/+ (n = 16),...
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